How I treat cancer: treatment of rheumatological side effects of immunotherapy

被引：11

作者：

Benesova, Karolina ^{[1
]}

Lorenz, Hanns-Martin ^{[1
]}

Leipe, Jan ^{[2
]}

Jordan, Karin ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Dept Med Hematol Oncol & Rheumatol 5, Heidelberg, Germany

[2] Univ Hosp Mannheim, Dept Med 5, Div Rheumatol, Mannheim, Germany

来源：

ESMO OPEN | 2019年 / 4卷

关键词：

IMMUNE CHECKPOINT INHIBITORS; ADVERSE EVENTS;

D O I：

10.1136/esmoopen-2019-000529

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rheumatic immune-related adverse events (irAEs) have long been underestimated. However, arthralgia or myalgia are common side effects of immune checkpoint inhibitors (ICPi) reported in up to 10-20% of patients in clinical trials. Although rheumatic irAEs are rarely life-threatening, patients' quality of life can be considerably restricted due to pain, stiffness and limited mobility. Rheumatic irAEs can resemble known rheumatic and musculoskeletal diseases (RMDs), but often do not fulfil the classification criteria of classical entities and standardised evidence-based guidelines for their management are so far lacking. Herein, we discuss specific characteristics of rheumatic irAEs and present a comprehensible diagnostic and therapeutic approach to the management of these side effects.

引用

页数：4

共 18 条

[1] Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer [J].

Arbour, Kathryn C. ;

Mezquita, Laura ;

Long, Niamh ;

Rizvi, Hira ;

Auclin, Edouard ;

Ni, Andy ;

Martinez-Bernal, Gala ;

Ferrara, Roberto ;

Lai, W. Victoria ;

Hendriks, Lizza E. L. ;

Sabari, Joshua K. ;

Caramella, Caroline ;

Plodkowski, Andrew J. ;

Halpenny, Darragh ;

Chaft, Jamie E. ;

Planchard, David ;

Riely, Gregory J. ;

Besse, Benjamin ;

Hellmann, Matthew D. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (28) :2872-+

[2] TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma [J].

Bertrand, Florie ;

Montfort, Anne ;

Marcheteau, Elie ;

Imbert, Caroline ;

Gilhodes, Julia ;

Filleron, Thomas ;

Rochaix, Philippe ;

Andrieu-Abadie, Nathalie ;

Levade, Thierry ;

Meyer, Nicolas ;

Colacios, Celine ;

Segui, Bruno .

NATURE COMMUNICATIONS, 2017, 8

[3] Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [J].

Brahmer, Julie R. ;

Lacchetti, Christina ;

Schneider, Bryan J. ;

Atkins, Michael B. ;

Brassil, Kelly J. ;

Caterino, Jeffrey M. ;

Chau, Ian ;

Ernstoff, Marc S. ;

Gardner, Jennifer M. ;

Ginex, Pamela ;

Hallmeyer, Sigrun ;

Chakrabarty, Jennifer Holter ;

Leighl, Natasha B. ;

Mammen, Jennifer S. ;

McDermott, David F. ;

Naing, Aung ;

Nastoupil, Loretta J. ;

Phillips, Tanyanika ;

Porter, Laura D. ;

Puzanov, Igor ;

Reichner, Cristina A. ;

Santomasso, Bianca D. ;

Seigel, Carole ;

Spira, Alexander ;

Suarez-Almazor, Maria E. ;

Wang, Yinghong ;

Weber, Jeffrey S. ;

Wolchok, Jedd D. ;

Thompson, John A. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) :1714-+

[4] Magnetic Resonance Imaging in Rheumatology [J].

Braun, J. ;

Baraliakos, X. .

ZEITSCHRIFT FUR RHEUMATOLOGIE, 2016, 75 (06) :582-585

[5] Characterization of arthralgia induced by PD-1 antibody treatment in patients with metastasized cutaneous malignancies [J].

Buder-Bakhaya, Kristina ;

Benesova, Karolina ;

Schulz, Carsten ;

Anwar, Hoda ;

Dimitrakopoulou-Strauss, Antonia ;

Weber, Tim F. ;

Enk, Alexander ;

Lorenz, Hanns-Martin ;

Hassel, Jessica C. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2018, 67 (02) :175-182

[6]

Calabrese C, 2017, RMD OPEN, V3, DOI 10.1136/rmdopen-2016-000412

[7] Rheumatic and Musculoskeletal Immune-Related Adverse Events Due to Immune Checkpoint Inhibitors: A Systematic Review of the Literature [J].

Cappelli, Laura C. ;

Gutierrez, Anna Kristina ;

Bingham, Clifton O., III ;

Shah, Ami A. .

ARTHRITIS CARE & RESEARCH, 2017, 69 (11) :1751-1763

[8] Mucosal Healing in Ulcerative Colitis: A Comprehensive Review [J].

Carvalho, Pedro Boal ;

Cotter, Jose .

DRUGS, 2017, 77 (02) :159-173

[9] Clinical Nononcologic Applications of PET/CT and PET/MRI in Musculoskeletal, Orthopedic, and Rheumatologic Imaging [J].

Gholamrezanezhad, Ali ;

Basques, Kyle ;

Batouli, Ali ;

Matcuk, George ;

Alavi, Abass ;

Jadvar, Hossein .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2018, 210 (06) :W245-W263

[10] Programmed cell death protein-1 (PD-1) inhibitor therapy in patients with advanced melanoma and preexisting autoimmunity or ipilimumab-triggered autoimmunity [J].

Gutzmer, Ralf ;

Koop, Anika ;

Meier, Friedegund ;

Hassel, Jessica C. ;

Terheyden, Patrick ;

Zimmer, Lisa ;

Heinzerling, Lucie ;

Ugurel, Selma ;

Pfoehler, Claudia ;

Gesierich, Anja ;

Livingstone, Elisabeth ;

Satzger, Imke ;

Kaehler, Katharina C. .

EUROPEAN JOURNAL OF CANCER, 2017, 75 :24-32

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