TSH receptor activation and body composition

被引：38

作者：

de Lloyd, Anna ^{[1
]}

Bursell, James ^{[2
]}

Gregory, John W. ^{[2
]}

Rees, D. Aled ^{[1
]}

Ludgate, Marian ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Ctr Endocrine & Diabet Sci, Cardiff CF14 4XN, S Glam, Wales

[2] Cardiff Univ, Sch Med, Dept Child Hlth, Cardiff CF14 4XN, S Glam, Wales

来源：

JOURNAL OF ENDOCRINOLOGY | 2010年 / 204卷 / 01期

关键词：

BROWN ADIPOSE-TISSUE; STIMULATING HORMONE-RECEPTOR; II IODOTHYRONINE DEIODINASE; THYROTROPIN-RECEPTOR; THYROID-HORMONE; GRAVES-DISEASE; SERUM TSH; GERMLINE MUTATIONS; GENE-EXPRESSION; CYCLIC-AMP;

D O I：

10.1677/JOE-09-0262

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impacts of hyper and hypothyroidism on body composition, i.e. the relative quantity and quality of bone, adipose tissue and muscle, have traditionally been attributed uniquely to abnormal levels of free thyroid hormones. The presence of biologically active TSH receptors in bone, fat and muscle, raises the possibility that both thyroid hormones and TSH contribute to the changes in body composition associated with thyroid disease. This review evaluates the evidence for this in terms of the in vitro experimental approaches applied, data from in vivo sources (i.e. mouse models) and patient-based studies. Journal of Endocrinology (2010) 204, 13-20

引用

页码：13 / 20

页数：8

共 84 条

[1] TSH is a negative regulator of skeletal remodeling [J].

Abe, E ;

Marians, RC ;

Yu, WQ ;

Wu, XB ;

Ando, T ;

Li, YN ;

Iqbal, J ;

Eldeiry, L ;

Rajendren, G ;

Blair, HC ;

Davies, TF ;

Zaidi, M .

CELL, 2003, 115 (02) :151-162

[2] Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism [J].

Alberti, L ;

Proverbio, MC ;

Costagliola, S ;

Romoli, R ;

Boldrighini, B ;

Vigone, MC ;

Weber, G ;

Chiumello, G ;

Beck-Peccoz, P ;

Persani, L .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (06) :2549-2555

[3] THYROID-HORMONES AND BONE [J].

ALLAIN, TJ ;

MCGREGOR, AM .

JOURNAL OF ENDOCRINOLOGY, 1993, 139 (01) :9-18

[4]

BAKER GR, 2004, END ABSTR, V7, pOC18

[5] A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism [J].

Bassett, J. H. Duncan ;

Williams, Allan J. ;

Murphy, Elaine ;

Boyde, Alan ;

Howell, Peter G. T. ;

Swinhoe, Rowan ;

Archanco, Marta ;

Flamant, Frederic ;

Samarut, Jacques ;

Costagliola, Sabine ;

Vassart, Gilbert ;

Weiss, Roy E. ;

Refetoff, Samuel ;

Williams, Graham R. .

MOLECULAR ENDOCRINOLOGY, 2008, 22 (02) :501-512

[6] Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism [J].

Bassett, J. H. Duncan ;

O'Shea, Patrick J. ;

Sriskantharajah, Srividya ;

Rabier, Benedicte ;

Boyde, Alan ;

Howell, Peter G. T. ;

Weiss, Roy E. ;

Roux, Jean-Paul ;

Malaval, Luc ;

Clement-Lacroix, Phillipe ;

Samarut, Jacques ;

Chassande, Olivier ;

Williams, Graham R. .

MOLECULAR ENDOCRINOLOGY, 2007, 21 (05) :1095-1107

[7] Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts [J].

Bell, A ;

Gagnon, A ;

Grunder, L ;

Parikh, SJ ;

Smith, TJ ;

Sorisky, A .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2000, 279 (02) :C335-C340

[8] Regulation of Wnt signaling during adipogenesis [J].

Bennett, CN ;

Ross, SE ;

Longo, KA ;

Bajnok, L ;

Hemati, N ;

Johnson, KW ;

Harrison, SD ;

MacDougald, OA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) :30998-31004

[9] Subclinical hyperthyroidism: clinical features and treatment options [J].

Biondi, B ;

Palmieri, EA ;

Klain, M ;

Schlumberger, M ;

Filetti, S ;

Lombardi, G .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 152 (01) :1-9

[10] The role of leptin in regulating neuroendocrine function in humans [J].

Blüher, S ;

Mantzoros, CS .

JOURNAL OF NUTRITION, 2004, 134 (09) :2469S-2474S

← 1 2 3 4 5 6 7 8 9 →