Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats

被引：25
作者：
Obradovic, Milan [1 ]
Sudar, Emina [1 ]
Zafirovic, Sonja [1 ]
Stanimirovic, Julijana [1 ]
Labudovic-Borovic, Milica [2 ]
Isenovic, Esma R. [1 ]
机构：
[1] Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia
[2] Univ Belgrade, Fac Med, Inst Histol & Embryol Aleksandar D Kostic, Belgrade 11000, Serbia
来源：
ANGIOLOGY | 2015年 / 66卷 / 01期
关键词：
estradiol; cardiac hypertrophy; obesity; IR; HIGH-FAT-DIET; ESTROGEN-RECEPTOR; INSULIN-RESISTANCE; HEART-DISEASE; ELECTROPHORETIC TRANSFER; POLYACRYLAMIDE-GELS; CHOLESTEROL LEVELS; HEPATIC STEATOSIS; ER-BETA; DYSFUNCTION;
D O I：
10.1177/0003319713514477
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 g/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt.
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收藏
页码：25 / 35
页数：11
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