Novel serine-based linker for the solid-phase synthesis of organic compounds

被引：16

作者：

Chou, YL ^{[1
]}

Morrissey, MM ^{[1
]}

Mohan, R ^{[1
]}

机构：

[1] Berlex Biosci, Pharmaceut Discovery, Richmond, CA 94804 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)10618-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel serine-derived Linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker is stable to acids such as TFA and bases such as pyrrolidine. The linker should provide utility in multi-step solid phase organic chemistry protocols where both acid and base chemistry is used. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：757 / 760

页数：4

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