Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain

被引:17
作者
Kurt, MA
Davies, DC
Kidd, M
机构
[1] St George Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 0RE, England
[2] Univ Uludag, Sch Med, Dept Anat, Bursa, Turkey
关键词
neurofibrillary tangles; neuropil threads; senile plaques; ultrastructure; pathogenesis;
D O I
10.1016/S0304-3940(97)00876-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Paired helical filaments (PHFs) are one of the hallmark pathologies of Alzheimer's disease (AD). PHFs occur in three intracellular locations, although hitherto, it was not known whether all PHFs are structurally homogeneous. Parietal cortex biopsies were taken from five patients with a clinical and histopathological diagnosis of AD and processed for electron microscopy. Photomicrographs were then taken of PHFs in neurofibrillary tangles (NFTs), neuropil threads (NTs) and neuritic plaque (NP) neurites and their dimensions measured. The mean half period, maximum and minimum widths of PHFs in NFTs were significantly smaller than those in NTs or NP neurites. The mean half period and maximum width of PHFs in NTs were similar to those in NP neurites. These results reveal the presence of two distinct PHF populations and investigation of their relationship may shed light on the pathogenesis of AD. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:41 / 44
页数:4
相关论文
共 50 条
[41]   Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition [J].
Zheng, Ling ;
Vinters, Harry V. ;
Mack, Wendy J. ;
Weiner, Michael W. ;
Chui, Helena C. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 (01) :204-215
[42]   A Look at the Etiology of Alzheimer's Disease based on the Brain Ischemia Model [J].
Pluta, Ryszard .
CURRENT ALZHEIMER RESEARCH, 2024, 21 (03) :166-182
[43]   Convergence between brain aging and Alzheimer's disease: Focus on mitochondria [J].
Vaiasicca, Salvatore ;
Balietti, Marta ;
Bevilacqua, Lisa ;
Giorgetti, Belinda ;
Casoli, Tiziana .
MECHANISMS OF AGEING AND DEVELOPMENT, 2024, 222
[44]   Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration [J].
Cortes-Canteli, Marta ;
Mattei, Larissa ;
Richards, Allison T. ;
Norris, Erin H. ;
Strickland, Sidney .
NEUROBIOLOGY OF AGING, 2015, 36 (02) :608-617
[45]   Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease [J].
de la Monte, Suzanne M. .
CURRENT ALZHEIMER RESEARCH, 2012, 9 (01) :35-66
[46]   Pathogenesis and Therapeutic Strategies in Alzheimer’s Disease: From Brain to Periphery [J].
Jin-Tai Yu ;
Can Zhang .
Neurotoxicity Research, 2016, 29 :197-200
[47]   Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer's Disease [J].
Hunter, Jesse M. ;
Kwan, Jason ;
Malek-Ahmadi, Michael ;
Maarouf, Chera L. ;
Kokjohn, Tyler A. ;
Belden, Christine ;
Sabbagh, Marwan N. ;
Beach, Thomas G. ;
Roher, Alex E. .
PLOS ONE, 2012, 7 (05)
[48]   Pathogenesis and Therapeutic Strategies in Alzheimer's Disease: From Brain to Periphery [J].
Yu, Jin-Tai ;
Zhang, Can .
NEUROTOXICITY RESEARCH, 2016, 29 (02) :197-200
[49]   Pros and Cons of Human Brain Organoids to Study Alzheimer's Disease [J].
Sainz, Andrea ;
Perez, Fernando ;
Perez-Samartin, Alberto ;
Panicker, Mitradas ;
Ruiz, Asier ;
Matute, Carlos .
AGING AND DISEASE, 2025,
[50]   Brain microbleeds and Alzheimer's disease: innocent observation or key player? [J].
Cordonnier, Charlotte ;
van der Flier, Wiesje M. .
BRAIN, 2011, 134 :335-344