Synthesis of Imidazole-Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications

被引：79
作者：
Song, Zhegang [1 ,2 ]
Zhang, Weijie [1 ,2 ]
Jiang, Meijuan [1 ,2 ]
Sung, Herman H. Y. [1 ,2 ]
Kwok, Ryan T. K. [1 ,2 ]
Nie, Han [3 ]
Williams, Ian D. [1 ,2 ]
Liu, Bin [4 ]
Tang, Ben Zhong [1 ,2 ,3 ,5 ]
机构：
[1] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Biomed Engn, Inst Adv Study,Div Life Sci,Dept Chem, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Hong Kong, Peoples R China
[3] S China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Innovat Res Team SCUT HKUST Joint Res L, Guangzhou 510640, Guangdong, Peoples R China
[4] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
[5] HKUST Shenzhen Res Inst, 9 Yuexing First RD, Shenzhen 518057, Peoples R China
来源：
ADVANCED FUNCTIONAL MATERIALS | 2016年 / 26卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
aggregation-induced emission; antifungal; imidazoles; mitochondria targeting; AGGREGATION-INDUCED EMISSION; IN-VITRO; BIOPROBES; MITOCHONDRIA; PROBES; DYES; SALT;
D O I：
10.1002/adfm.201503788
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Research on aggregation-induced emission (AIE) has become increasingly popular recently and various AIE luminogens (AIEgens) have been developed based on tetraphenylethene, hexaphenylsilole, distyrylanthracene, tetraphenylpyrazine, etc. However, facile tuning of the AIEgen emissions in a wide range remains challenging. Herein, a novel series of AIEgens is reported, based on imidazole-cored molecular rotors, with facile synthesis and emission colors covering the whole visible spectrum. Moreover, these imidazole derivatives exhibit biological functions unique among the AIEgens, including mitochondria-specific imaging and antifungal activity. Benefiting from the easy preparation and the tunable emission, the imidazole derivatives are expected to not only diversify the family of AIEgens but also enrich their biological applications.
引用
收藏
页码：824 / 832
页数：9
相关论文
共 41 条
[1]   Synthesis, light emission, nanoaggregation, and restricted intramolecular rotation of 1,1-substituted 2,3,4,5-tetraphenylsiloles [J].
Chen, JW ;
Law, CCW ;
Lam, JWY ;
Dong, YP ;
Lo, SMF ;
Williams, ID ;
Zhu, DB ;
Tang, BZ .
CHEMISTRY OF MATERIALS, 2003, 15 (07) :1535-1546
[2]   Tetraphenylpyrazine-based AIEgens: facile preparation and tunable light emission [J].
Chen, Ming ;
Li, Lingzhi ;
Nie, Han ;
Tong, Jiaqi ;
Yan, Lulin ;
Xu, Bin ;
Sun, Jing Zhi ;
Tian, Wenjing ;
Zhao, Zujin ;
Qin, Anjun ;
Tang, Ben Zhong .
CHEMICAL SCIENCE, 2015, 6 (03) :1932-1937
[3]   Characterization and in vitro antitumor activity of polysaccharides from the mycelium of Sarcodon aspratus [J].
Chen, Yan ;
Hu, Meili ;
Wang, Cui ;
Yang, Yuling ;
Chen, Jianhua ;
Ding, Jingna ;
Guo, Wenqiang .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 52 :52-58
[4]   Bioprobes Based on AIE Fluorogens [J].
Ding, Dan ;
Li, Kai ;
Liu, Bin ;
Tang, Ben Zhong .
ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (11) :2441-2453
[5]   Aggregation-induced emissions of tetraphenylethene derivatives and their utilities as chemical vapor sensors and in organic light-emitting diodes [J].
Dong, Yongqiang ;
Lam, Jacky W. Y. ;
Qin, Anjun ;
Liu, Jianzhao ;
Li, Zhen ;
Tang, Ben Zhong .
APPLIED PHYSICS LETTERS, 2007, 91 (01)
[6]   Ionic liquid (molten salt) phase organometallic catalysis [J].
Dupont, J ;
de Souza, RF ;
Suarez, PAZ .
CHEMICAL REVIEWS, 2002, 102 (10) :3667-3691
[7]   Photoluminescence and electroluminescence of hexaphenylsilole are enhanced by pressurization in the solid state [J].
Fan, Xing ;
Sun, Jianliang ;
Wang, Fuzhi ;
Chu, Zengze ;
Wang, Ping ;
Dong, Yongqiang ;
Hu, Rongrong ;
Tang, Ben Zhong ;
Zou, Dechun .
CHEMICAL COMMUNICATIONS, 2008, (26) :2989-2991
[8]   Monitoring clinical levels of heparin in human blood samples with an indicator-displacement assay [J].
Francoia, Jean-Patrick ;
Pascal, Robert ;
Vial, Laurent .
CHEMICAL COMMUNICATIONS, 2015, 51 (10) :1953-1956
[9]   Imaging Self-Assembly Dependent Spatial Distribution of Small Molecules in a Cellular Environment [J].
Gao, Yuan ;
Kuang, Yi ;
Du, Xuewen ;
Zhou, Jie ;
Chandran, Preethi ;
Horkay, Ferenc ;
Xu, Bing .
LANGMUIR, 2013, 29 (49) :15191-15200
[10]   Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance [J].
Ghannoum, MA ;
Rice, LB .
CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (04) :501-+
12345