Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry

被引：51

作者：

Macià, A ^{[1
]}

Borrull, F ^{[1
]}

Calull, M ^{[1
]}

Aguilar, C ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Dept Quim Analit & Quim Organ, E-43005 Tarragona, Spain

来源：

ELECTROPHORESIS | 2004年 / 25卷 / 20期

关键词：

capillary electrophoresis; dynamic coated capillaries; mass spectrometry; water samples;

D O I：

10.1002/elps.200406067

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe an analytical method involving solid-phase extraction (SPE) and capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) for determining some pharmaceutical compounds - naproxen, clofibric acid and bezafibrate - in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous-organic solvent and CZE-ESI-MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from offline SPE-CZE-IVIS and was validated with surface water. The detection limits were 100 mug - L-1 for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid-liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits.

引用

页码：3441 / 3449

页数：9

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