Transcription factors as targets for cancer therapy

被引：954

作者：

Darnell, JE ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Mol Cell Biol, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 10期

关键词：

D O I：

10.1038/nrc906

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?.

引用

页码：740 / 749

页数：10

共 109 条

[1] On the offensive [J].

Abbott, A .

NATURE, 2002, 416 (6880) :470-474

[2] Cooperation among Stat1, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fcγ receptor I in monocytes [J].

Aittomäki, S ;

Pesu, M ;

Groner, B ;

Jänne, OA ;

Palvimo, JJ ;

Silvennoinen, O .

JOURNAL OF IMMUNOLOGY, 2000, 164 (11) :5689-5697

[3] Gli proteins and Hedgehog signaling - development and cancer [J].

Altaba, ARI .

TRENDS IN GENETICS, 1999, 15 (10) :418-425

[4] RETRACTED: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus (Retracted article. See vol. 27, pg. 1982, 2013) [J].

Aoki, N ;

Matsuda, T .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (01) :58-69

[5] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[6]

Bachur N R., 2002, Encyclopedia of Cancer, P57

[7]

Barish GD, 2000, CANC DRUG DISC DEV, V5, P53

[8]

Barker N, 2000, BIOESSAYS, V22, P961

[9] Anti-inflammatory actions of glucocorticoids: molecular mechanisms [J].

Barnes, PJ .

CLINICAL SCIENCE, 1998, 94 (06) :557-572

[10] Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts [J].

Berg, T ;

Cohen, SB ;

Desharnais, J ;

Sonderegger, C ;

Maslyar, DJ ;

Goldberg, J ;

Boger, DL ;

Vogt, PK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3830-3835

← 1 2 3 4 5 6 7 8 9 10 →