Transcription factors as targets for cancer therapy

被引：942

作者：

Darnell, JE ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Mol Cell Biol, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 10期

关键词：

D O I：

10.1038/nrc906

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?.

引用

页码：740 / 749

页数：10

共 109 条

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