Control systems and decision making for antibody production

被引：308
作者：
Goodnow, Christopher C. [1 ]
Vinuesa, Carola G. [1 ]
Randall, Katrina L. [1 ,2 ]
Mackay, Fabienne [3 ]
Brink, Robert [4 ,5 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
[2] Canberra Hosp, Dept Immunol, Garran, ACT, Australia
[3] Monash Univ, Dept Immunol, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia
[4] Garvan Inst Med Res, Darlinghurst, NSW, Australia
[5] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia
来源：
NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院;
关键词：
B-CELL RECEPTOR; PRIMARY IMMUNE-RESPONSE; HELPER T-CELLS; GERMINAL-CENTER; PLASMA-CELLS; ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL; 3-KINASE; AFFINITY MATURATION; DENDRITIC CELLS; SELF-TOLERANCE;
D O I：
10.1038/ni.1900
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.
引用
收藏
页码：681 / 688
页数：8
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