TFG: a novel regulator of ULK1-dependent autophagy

被引：0
|
作者：
Cecconi, Francesco [1 ,2 ,3 ]
Nazio, Francesca [1 ]
机构：
[1] IRCCS, Bambino Gesu Childrens Hosp, Dept Pediat Hematooncol & Cell & Gene Theraphy, Viale San Paolo 15, I-00146 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Biol, Rome, Italy
[3] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, Copenhagen, Denmark
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 04期
关键词：
ULK1; ERGIC; TFG; omegasome; neurological disorders;
D O I：
10.1080/23723556.2021.1945895
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.
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页数：3
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