Pivotal role of plasminogen-activator inhibitor 1 in vascular disease

被引：61
作者：
Agirbasli, M [1 ]
机构：
[1] Marmara Univ, Med Ctr, Div Cardiol, Istanbul, Turkey
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2005年 / 59卷 / 01期
关键词：
plasminogen-activator inhibitor 1; atherosclerosis; thrombosis;
D O I：
10.1111/j.1742-1241.2005.00379.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibrinolysis plays a crucial role in the development of vascular disease. The interface between the plasminogen activators and inhibitors determines the fibrinolytic potential of human blood. In addition to fibrin degradation, fibrinolytic system components modulate several complex biological events such as angiogenesis, tumorigenesis, arteriosclerosis and cellular migration. Recent experimental and clinical data indicated that PAI-1 as a novel vascular risk factor. In this concise review, we will examine the accumulating evidence suggesting that there is an intricate relationship between these systems which may provide new therapeutic strategies for prevention of vascular disease. (C) 2005 Blackwell Publishing Ltd.
引用
收藏
页码：102 / 106
页数：5
相关论文
共 42 条
  • [1] CRYSTALLIZATION AND X-RAY-DIFFRACTION DATA OF THE CLEAVED FORM OF PLASMINOGEN-ACTIVATOR INHIBITOR-1
    AERTGEERTS, K
    DEBONDT, HL
    DERANTER, C
    DECLERCK, PJ
    [J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1995, 23 (01): : 118 - 121
  • [2] The plasminogen activation system in tumor growth, invasion, and metastasis
    Andreasen, PA
    Egelund, R
    Petersen, HH
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (01) : 25 - 40
  • [3] DIURNAL-VARIATION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR AND ITS RAPID INHIBITOR (PAI-1)
    ANGLETON, P
    CHANDLER, WL
    SCHMER, G
    [J]. CIRCULATION, 1989, 79 (01) : 101 - 106
  • [4] BOSMA PJ, 1991, J BIOL CHEM, V266, P17845
  • [5] XR5967, a novel modulator of plasminogen activator inhibitor-1 activity, suppresses tumor cell invasion and angiogenesis in vitro
    Brooks, TD
    Wang, SMW
    Brünner, N
    Charlton, PA
    [J]. ANTI-CANCER DRUGS, 2004, 15 (01) : 37 - 44
  • [6] Effect of activation and inhibition of the renin-angiotensin system on plasma PAI-1
    Brown, NJ
    Agirbasli, MA
    Williams, GH
    Litchfield, WR
    Vaughan, DE
    [J]. HYPERTENSION, 1998, 32 (06) : 965 - 971
  • [7] Brown NJ, 1997, THROMB HAEMOSTASIS, V77, P522
  • [8] CHANDLER WL, 1991, THROMB HAEMOSTASIS, V66, P321
  • [9] CHEN YC, 1998, J BIOL CHEM, V273, P18268
  • [10] COLEMAN PL, 1982, J BIOL CHEM, V257, P4260
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