Inducible expression of defensins and cathelicidins by nutrients and associated regulatory mechanisms

被引：29

作者：

Chen, Jialuo ^{[1
]}

Zhai, Zhenya ^{[1
]}

Long, Hongrong ^{[1
]}

Yang, Guangming ^{[1
]}

Deng, Baichuan ^{[1
]}

Deng, Jinping ^{[1
]}

机构：

[1] South China Agr Univ, Coll Anim Sci, Subtrop Inst Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China

来源：

PEPTIDES | 2020年 / 123卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Nutrients; Inducible expression; Defensins; Cathelicidins; Regulatory mechanisms; PEPTIDE GENE-EXPRESSION; VITAMIN-D-RECEPTOR; NF-KAPPA-B; MAMMARY EPITHELIAL-CELLS; PORCINE BETA-DEFENSINS; CHAIN FATTY-ACIDS; ANTIMICROBIAL PEPTIDES; L-ISOLEUCINE; GREEN TEA; BARRIER FUNCTION;

D O I：

10.1016/j.peptides.2019.170177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Host defense peptides (HDPs) are crucial components of the body's first line of defense that protect organisms from infections and mediate immune responses. Defensins and cathelicidins are the two most important families of HDPs in mammals. In this review, we summarize the nutrients that are involved in inducible expression of endogenous defensins and cathelicidins. In addition, the mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-kappa B) and histone deacetylase (HDAC) signaling pathways that play vital roles in the induction of defensin and cathelicidin expression are highlighted. Endogenous defensins and cathelicidins induced by nutrients may be potential alternatives to antibiotic treatments against infection and diseases. This review mainly focuses on the inducible expression and regulatory mechanisms of defensins and cathelicidins in multiple species by different nutrients and the potential applications of defensin- and cathelicidin-inducing nutrients.

引用

页数：8

共 116 条

[21] Ascorbic Acid, Ultraviolet C Rays, and Glucose but not Hyperthermia Are Elicitors of Human β-Defensin 1 mRNA in Normal Keratinocytes [J].