Hepatitis C virus genotypes in Hungarian and Austrian patients with chronic hepatitis C

被引：8

作者：

Müller, Z

Deák, J

Ross, RS

Nagy, E

Kovács, L

Roggendorf, M

Kessler, HH

机构：

[1] Univ Szeged, Dept Clin Microbiol, H-6725 Szeged, Hungary

[2] Essen Univ Hosp, Inst Virol, D-45122 Essen, Germany

[3] Univ Szeged, Dept Obstet & Gynecol, H-6725 Szeged, Hungary

[4] Karl Franzens Univ Graz, Mol Diagnost Lab, Inst Hyg, A-8010 Graz, Austria

来源：

JOURNAL OF CLINICAL VIROLOGY | 2003年 / 26卷 / 03期

关键词：

HCV; genotype; sequencing; Austria; Hungary;

D O I：

10.1016/S1386-6532(02)00045-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) genotypes are relevant to epidemiological questions, vaccine development, and clinical management of chronic HCV infection. The aim of this study was to determine HCV genotypes of South Hungarian and Southeast Austrian patients with chronic hepatitis C. Results were obtained by the largely automated TruGene HCV 5'NC Genotyping Kit (Visible Genetics, Toronto, Ontario) and by phylogenetic analysis. All of the 20 Hungarian patients and 15 out of 20 Austrian patients were infected with genotype 1. The remaining Austrian patients were infected with genotypes 3 or 2. With the commercially available assay, it was not possible to determine the HCV subtype in a total of three patients. The TruGene HCV 5'NC Genotyping assay for the determination of HCV genotypes proved to be useful for a high-throughput routine diagnostic laboratory. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：295 / 300

页数：6

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