Contemporary Trends and Efficacy of Pelvic Lymph Node Dissection at Radical Cystectomy for Urothelial and Variant Histology Carcinoma of the Urinary Bladder

被引：5

作者：

Kosiba, Marina ^{[1
,2
]}

Stolzenbach, L. Franziska ^{[2
,3
]}

Ruvolo, Claudia Colla ^{[2
,4
]}

Nocera, Luigi ^{[2
,5
,6
]}

Mansour, Mila ^{[2
]}

Tian, Zhe ^{[2
]}

Roos, Frederik C. ^{[1
]}

Becker, Andreas ^{[1
]}

Kluth, Luis A. ^{[1
]}

Tilki, Derya ^{[3
]}

Shariat, Shahrokh F. ^{[7
,8
,9
]}

Saad, Fred ^{[2
]}

Chun, Felix K. H. ^{[1
]}

Karakiewicz, Pierre, I ^{[2
]}

机构：

[1] Univ Hosp Frankfurt, Dept Urol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany

[2] Univ Montreal, Div Urol, Canc Prognost & Hlth Outcomes Unit, Hlth Ctr, Montreal, PQ, Canada

[3] Univ Hosp Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Hamburg, Germany

[4] Univ Naples Federico II, Dept Urol, Naples, Italy

[5] Ist Sci San Raffaele, Urol Res Inst, Dept Urol, URI, Milan, Italy

[6] Ist Sci San Raffaele, Urol Res Inst, Div Expt Oncol, URI, Milan, Italy

[7] Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria

[8] IM Sechenov First Moscow State Med Univ, Inst Urol & Reprod Hlth, Moscow, Russia

[9] Univ Jordan, Dept Urol, Amman, Jordan

来源：

CLINICAL GENITOURINARY CANCER | 2022年 / 20卷 / 02期

关键词：

Bladder cancer; Squamous cell carcinoma; Adenocarcinoma; Neuroendocrine carcinoma; Number of nodes removed; Extended lymph node dissection; extensive lymph node dissection; annual treatment rates; CANCER; LYMPHADENECTOMY; IMPACT; EXTENT; SURVIVAL;

D O I：

10.1016/j.clgc.2021.10.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Contemporary pelvic lymph node dissection (PLND) rates at radical cystectomy increased over time in variant histology bladder cancer (VHBC) and urothelial carcinoma of the urinary bladder (UCUB) patients. A potential survival benefit related to more extensive PLND is operational in UCUB patients, but not in VHBC patients. Rates of lymph node invasion increased slightly with extent of PLND. Objective: To test 1) contemporary pelvic lymph node dissection (PLND) trends at radical cystectomy (RC) in variant histology bladder cancer (VHBC) patients and urothelial carcinoma of the urinary bladder (UCUB), as well as 2) to test the effect of PLND extent on cancer specific mortality (CSM) after RC. Methods: Within the Surveillance, Epidemiology and End Results Registry (SEER, 2004-2016), we identified non-metastatic stage T1-2 or T3-4 VHBC and UCUB patients, who underwent RC. CSM and lymph node invasion (LNI) rates were stratified according to PLND extent, as well as coded continuously in multivariate Cox and logistic regression models. Results: Of 19,020 patients, 1736 (9.1%) were coded as having VHBC (46.9% squamous cell carcinoma, 22.5% adenocarcinoma, 18.9% neuroendocrine carcinoma, 11.7% not otherwise specified) vs 17,284 (90.9%) UCUB. PLND was performed in 80.1 of VHBC vs. 83.5% UCUB patients. In both histological groups, PLND rates increased over time (70.9-89.6% and 76.2%-90.1%, both P < .01). PLND extent did not significantly affect CSM in stage T1-2 or T3-4 VHBC patients. Conversely, PLND extent was associated with lower CSM in T1-2, as well as in T3-4 UCUB patients, which was confirmed in multivariate Cox analyses (Hazard ratio [HR] 0.99, P < .001). Rates of LNI increased with extent of PLND in logistic regression analyses in stage T3-4 VHBC (Odds ratio [OR] 1.01, P = .001), stage T1-2 UCUB (OR 1.01, P < .001) and T3-4 UCUB (OR 1.01, P < .001), but not in stage T1-2 VHBC (OR 1.01, P = .3). Conclusion: PLND rates do not differ between VHBC and UCUB patients. A potential survival benefit related to more extensive PLND is operational in UCUB patients, but not in VHBC patients. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：195.e1 / 195.e8

页数：8

共 22 条

[1] Does the Extent of Lymphadenectomy in Radical Cystectomy for Bladder Cancer Influence Disease-Free Survival? A Prospective Single-Center Study [J].