Design, Synthesis, Docking and In Vitro Antibacterial Study of Fluoro Substituted Schiff Bases

被引：0

作者：

Hameed, Kehkashan ^{[1
]}

Gilani, Syeda Rubina ^{[1
]}

Raheel, Ahmad ^{[2
]}

Taj, Babar ^{[2
]}

Iftikhar, Syed Hussan ^{[1
]}

Imtiaz-ud-Din ^{[2
]}

Sadiqa, Ayesha ^{[1
]}

Aslam, Ambreen ^{[3
]}

机构：

[1] Univ Engn & Technol, Dept Chem, Lahore 54890, Pakistan

[2] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[3] Univ Lahore, Dept Environm Sci, Lahore 45320, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2018年 / 40卷 / 04期

关键词：

Fluoro substituted Schiff bases; Molecular docking; Bactericidal activity; Anti-cancer; ANTIMICROBIAL ACTIVITY; METAL-COMPLEXES; ISATIN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five new fluoro-substituted imines were synthesized by the reaction of different aldehydes with fluoro-substituted anilines. The synthesized compounds were characterized by elemental (CHN) analysis, FT-IR and multinuclear (H-1 and C-13) NMR spectroscopy. These compounds were also preliminary analyzed for bactericidal and anti-cancer activities. Molecular docking of these newly synthesized compounds supports the experimental results (bactericidal activity). The data suggests that these compounds display favorable bactericidal and anti-cancer activity and may prove potential candidate for drugs.

引用

页码：782 / 791

页数：10

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