Complexity and simplicity in the biosynthesis of enediyne natural products

被引：59

作者：

Liang, Zhao-Xun ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Biol Sci, Div Chem Biol & Biotechnol, Singapore 637551, Singapore

来源：

NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 04期

关键词：

ANTITUMOR ANTIBIOTIC C-1027; 6-METHYLSALICYLIC ACID SYNTHASE; 4-METHYLIDENEIMIDAZOLE-5-ONE-CONTAINING TYROSINE AMINOMUTASE; ANTIBODY-TARGETED CHEMOTHERAPY; I POLYKETIDE SYNTHASE; ACYL CARRIER PROTEIN; NEOCARZINOSTATIN CHROMOPHORE; KEDARCIDIN CHROMOPHORE; CRYSTAL-STRUCTURE; GENE-CLUSTER;

D O I：

10.1039/b908165h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review highlights the recent progress on the elucidation of the biosynthetic mechanism of enediyne natural products. A large body of knowledge has been gathered from the genetic, biochemical and structural studies since the sequencing of the first two enediyne gene clusters in 2002. Primary attention is devoted to the novel pathways and enzymes in the biosynthesis of the enediyne warhead as well as the peripheral moieties.

引用

页码：499 / 528

页数：30

共 213 条

[1] 3-DIMENSIONAL SOLUTION STRUCTURE OF APO-NEOCARZINOSTATIN FROM STREPTOMYCES-CARZINOSTATICUS DETERMINED BY NMR-SPECTROSCOPY [J].

ADJADJ, E ;

QUINIOU, E ;

MISPELTER, J ;

FAVAUDON, V ;

LHOSTE, JM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 203 (03) :505-511

[2] The calicheamicin gene cluster and its iterative type I enediyne PKS [J].

Ahlert, J ;

Shepard, E ;

Lomovskaya, N ;

Zazopoulos, E ;

Staffa, A ;

Bachmann, BO ;

Huang, KX ;

Fonstein, L ;

Czisny, A ;

Whitwam, RE ;

Farnet, CM ;

Thorson, JS .

SCIENCE, 2002, 297 (5584) :1173-1176

[3] Structural basis for macrolactonization by the pikromycin thioesterase [J].

Akey, David L. ;

Kittendorf, Jeffrey D. ;

Giraldes, John W. ;

Fecik, Robert A. ;

Sherman, David H. ;

Smith, Janet L. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (10) :537-542

[4] A new non-protein enediyne antibiotic N1999A2: Unique enediyne chromophore similar to neocarzinostatin and DNA cleavage feature [J].

Ando, T ;

Ishii, M ;

Kajiura, T ;

Kameyama, T ;

Miwa, K ;

Sugiura, Y .

TETRAHEDRON LETTERS, 1998, 39 (36) :6495-6498

[5] Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic [J].

Baker, James R. ;

Woolfson, Derek N. ;

Muskett, Frederick W. ;

Stoneman, Rhys G. ;

Urbaniak, Michael D. ;

Caddick, Stephen .

CHEMBIOCHEM, 2007, 8 (07) :704-717

[6] THE MULTIFUNCTIONAL 6-METHYLSALICYLIC ACID SYNTHASE GENE OF PENICILLIUM-PATULUM - ITS GENE STRUCTURE RELATIVE TO THAT OF OTHER POLYKETIDE SYNTHASES [J].

BECK, J ;

RIPKA, S ;

SIEGNER, A ;

SCHILTZ, E ;

SCHWEIZER, E .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 192 (02) :487-498

[7] EXPRESSION OF A FUNCTIONAL FUNGAL POLYKETIDE SYNTHASE IN THE BACTERIUM STREPTOMYCES-COELICOLOR A3(2) [J].

BEDFORD, DJ ;

SCHWEIZER, E ;

HOPWOOD, DA ;

KHOSLA, C .

JOURNAL OF BACTERIOLOGY, 1995, 177 (15) :4544-4548

[8] C-1027, A Radiomimetic Enediyne Anticancer Drug, Preferentially Targets Hypoxic Cells [J].

Beerman, Terry A. ;

Gawron, Loretta S. ;

Shin, Seulkih ;

Shen, Ben ;

McHught, Mary M. .

CANCER RESEARCH, 2009, 69 (02) :593-598

[9] Production of Octaketide Polyenes by the Calicheamicin Polyketide Synthase CalE8: Implications for the Biosynthesis of Enediyne Core Structures [J].

Belecki, Katherine ;

Crawford, Jason M. ;

Townsend, Craig A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (35) :12564-+

[10] Resistance to enediyne antitumor antibiotics by calC self-sacrifice [J].

Biggins, JB ;

Onwueme, KC ;

Thorson, JS .

SCIENCE, 2003, 301 (5639) :1537-1541

← 1 2 3 4 5 6 7 8 9 10 →