Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

被引：184

作者：

Seo, Boram ^{[1
,5
]}

Jeon, Kyungchan ^{[1
]}

Moon, Sunghyun ^{[1
,4
]}

Lee, Kiuk ^{[4
]}

Kim, Woon-Ki ^{[1
]}

Jeong, Hyein ^{[1
]}

Cha, Kwang Hyun ^{[6
]}

Lim, Mi Young ^{[7
]}

Kang, Wondae ^{[8
]}

Kweon, Mi-Na ^{[9
]}

Sung, Joohon ^{[10
]}

Kim, Won ^{[11
]}

Park, Joo-Hong ^{[5
]}

Ko, GwangPyo ^{[1
,2
,3
,4
]}

机构：

[1] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth Sci, Seoul, South Korea

[2] Seoul Natl Univ, BioMAX N Bio, Seoul, South Korea

[3] Seoul Natl Univ, Ctr Human & Environm Microbiome, Inst Hlth & Environm, Seoul, South Korea

[4] KoBioLabs Inc, Seoul, South Korea

[5] Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea

[6] KIST, Funct Food Ctr, Kangnung, South Korea

[7] Korea Food Res Inst, Res Grp Healthcare, Wonju, South Korea

[8] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea

[9] Univ Ulsan, Dept Convergence Med, Mucosal Immunol Lab, Coll Med,Asan Med Ctr, Seoul, South Korea

[10] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Epidemiol, Seoul, South Korea

[11] Seoul Natl Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Boramae Med Ctr,Seoul Metropolitan Govt, Seoul, South Korea

来源：

CELL HOST & MICROBE | 2020年 / 27卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

TOLL-LIKE RECEPTOR-4; INTESTINAL MICROBIOTA; DISEASE PATHOGENESIS; BARRIER DYSFUNCTION; ASIAN PATIENTS; PROTECTS MICE; INJURY; INFLAMMATION; STEATOHEPATITIS; MORTALITY;

D O I：

10.1016/j.chom.2019.11.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has previously been suggested, the causative effects of specific taxa and their functions have not been fully investigated to date. Here, we analyze the gut microbiota of 410 fecal samples from 212 Korean twins by using the Alcohol Use Disorders Identification Test (AUDIT) scales to adjust for host genetics. This analysis revealed a strong association between low AUDIT scores and the abundance of the butyrate-producing genus Roseburia. When Roseburia spp. are administered to ALD murine models, both hepatic steatosis and inflammation significantly improve regardless of bacterial viability. Specifically, the flagellin of R. intestinalis, possibly through Toll-like receptor 5 (TLR5) recognition, recovers gut barrier integrity through upregulation of the tight junction protein Occludin and helps to restore the gut microbiota through elevated expression of IL-22 and REG3 gamma. Our study demonstrates that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALDs.

引用

页码：25 / +

页数：22

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