Hypertension: Potential Player in Cardiovascular Disease Incidence in Preeclampsia

被引：5

作者：

Amini, Parya ^{[1
]}

Amrovani, Mehran ^{[2
]}

Nassaj, Zohre Saleh ^{[3
]}

Ajorlou, Parisa ^{[4
]}

Pezeshgi, Aiyoub ^{[5
]}

Ghahrodizadehabyaneh, Bahareh ^{[6
]}

机构：

[1] Ahvaz Jundishapour Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran

[2] High Inst Educ & Res Transfus Med, Tehran, Iran

[3] Shahroud Univ Med Sci, Ctr Hlth Related Social & Behav Sci Res, Shahroud, Iran

[4] Hormozgan Univ Med Sci, Fac Med, Dept Med Genet, Bandar Abbas, Iran

[5] Zanjan Univ Med Sci, Internal Med Dept, Zanjan, Iran

[6] Univ Tehran Med Sci, Med Fac, Obstet & Gynecol, Tehran, Iran

来源：

CARDIOVASCULAR TOXICOLOGY | 2022年 / 22卷 / 05期

关键词：

Hypertension; Cardiovascular disease; Preeclampsia; Mechanism; ATRIAL-NATRIURETIC-PEPTIDE; RENIN-ANGIOTENSIN SYSTEM; NF-KAPPA-B; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; RISK-FACTORS; ACTIVATION; PATHWAY;

D O I：

10.1007/s12012-022-09734-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preeclampsia (PE) is one of the complications, that threatens pregnant mothers during pregnancy. According to studies, it accounts for 3-7% of all pregnancies, and also is effective in preterm delivery. PE is the third leading cause of death in pregnant women. High blood pressure in PE can increase the risk of developing cardiovascular disease (CVD) in cited individuals, and is one of the leading causes of death in PE individuals. Atrial natriuretic peptide (ANP), Renin-Angiotensin system and nitric oxide (NO) are some of involved factors in regulating blood pressure. Therefore, by identifying the signaling pathways, that are used by these molecules to regulate and modulate blood pressure, appropriate treatment strategies can be provided to reduce blood pressure through target therapy in PE individuals; consequently, it can reduce CVD risk and mortality.

引用

页码：391 / 403

页数：13

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