Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

被引：24

作者：

Li, FG

Liu, JG

Mayne, R

Wu, CY

机构：

[1] UNIV ALABAMA, DEPT CELL BIOL, BIRMINGHAM, AL 35294 USA

[2] UNIV ALABAMA, CELL ADHES & MATRIX RES CTR, BIRMINGHAM, AL 35294 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1997年 / 1358卷 / 03期

关键词：

integrin-linked kinase; protein kinase; signal transduction; integrin; chromosomal mapping; tumorigenesis; (human); (mouse);

D O I：

10.1016/S0167-4889(97)00089-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrin-linked kinase (ILK) is a recently identified human protein kinase that has been implicated in integrin-mediated signal transduction and tumorigenesis. We have identified a mouse molecule that is highly homologous to human ILK. The mouse ILK homologue protein is readily recognized by antibodies raised against the human ILK protein, and the gene encoding the mouse ILK homologue is widely expressed in mouse tissues. The mouse ILK homologue gene has been mapped to chromosome 7E1 band. A second locus in the mouse chromosome 9E1-3 region has also been detected with a mouse ILK homologue cDNA probe by fluorescence in situ hybridization, suggesting the possible existence of an ILK pseudo-gene or a family of ILK genes in the mouse. (C) 1997 Elsevier Science B.V.

引用

页码：215 / 220

页数：6

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