Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex

被引：68
|
作者：
Chakrapani, H [1 ]
Liu, C [1 ]
Widenhoefer, RA [1 ]
机构：
[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 02期
关键词：
D O I：
10.1021/ol027196n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Reaction of 4,4-dicarbomethoxy-1-octene-6-yne (1) with triethylsilane and a catalytic 1:1 mixture of [Rh(COD)(2)](+) SbF6- and (R)-BIPHEMP (5 mol %) at 70 degreesC for 90 min gave (2)-1,1-dicarbomethoxy-3-(l-triethylsilyl)ethylidene-4-methylcyclopentane (2) in 81% isolated yield with 98% de and 92% ee.
引用
收藏
页码：157 / 159
页数：3
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