Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex

被引：70

作者：

Chakrapani, H ^{[1
]}

Liu, C ^{[1
]}

Widenhoefer, RA ^{[1
]}

机构：

[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1021/ol027196n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Reaction of 4,4-dicarbomethoxy-1-octene-6-yne (1) with triethylsilane and a catalytic 1:1 mixture of [Rh(COD)(2)](+) SbF6- and (R)-BIPHEMP (5 mol %) at 70 degreesC for 90 min gave (2)-1,1-dicarbomethoxy-3-(l-triethylsilyl)ethylidene-4-methylcyclopentane (2) in 81% isolated yield with 98% de and 92% ee.

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页码：157 / 159

页数：3

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