Metal free, "click and click-click" conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase

被引：16

作者：

Singh, Ishwar ^{[1
]}

Heaney, Frances ^{[1
]}

机构：

[1] NUI Maynooth, Dept Chem, Maynooth, Kildare, Ireland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

1,3-DIPOLAR CYCLOADDITION; TERMINAL ALKYNES; IN-VIVO; CHEMISTRY; DNA; DELIVERY; OLIGONUCLEOTIDES; NUCLEOSIDE; STRATEGIES; ANTISENSE;

D O I：

10.1039/b918463e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast and practical metal free conjugation of ribonucleosides and 2'-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3'- or the 5'-terminus of the oligoribonucleotide substrate.

引用

收藏

页码：451 / 456

页数：6

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