MPTP as a mitochondrial neurotoxic model of Parkinson's disease

被引：243
作者：
Przedborski, S [1 ]
Tieu, K
Perier, C
Vila, M
机构：
[1] Columbia Univ, Dept Neurol, New York, NY 10032 USA
[2] Columbia Univ, Dept Pathol, New York, NY 10032 USA
[3] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2004年 / 36卷 / 04期
关键词：
MPTP; Parkinson's disease; neurodegeneration; mitochondria; oxidative stress; ATP depletion; programmed cell death;
D O I：
10.1023/B:JOBB.0000041771.66775.d5
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.
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收藏
页码：375 / 379
页数：5
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