Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities

被引：5
|
作者：
Yan, Bing-Chao [1 ,2 ,3 ]
Wang, Wei-Guang [1 ,2 ]
Kong, Ling-Mei [1 ,2 ]
Tang, Jian-Wei [1 ,2 ,3 ]
Du, Xue [1 ,2 ,3 ]
Li, Yan [1 ,2 ]
Puno, Pema-Tenzin [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF FUNGI | 2022年 / 8卷 / 05期
基金：
中国国家自然科学基金;
关键词：
endophytic fungus; Phomopsis; cytochalasan; antimigratory activity; DERIVATIVES;
D O I：
10.3390/jof8050543
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1-7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1-3 and 8-11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC50 values in the range of 1.01-10.42 mu M.
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页数：10
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