Entecavir versus tenofovir in patients with chronic hepatitis B: Enemies or partners in the prevention of hepatocellular carcinoma

被引：39

作者：

Lee, Sung Won ^{[1
,2
]}

Choi, Jonggi ^{[3
]}

Kim, Seung Up ^{[4
,5
]}

Lim, Young-Suk ^{[3
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Catholic Univ, Liver Res Ctr, Seoul, South Korea

[3] Univ Ulsan, Liver Ctr, Asan Med Ctr, Dept Gastroenterol,Coll Med, Seoul, South Korea

[4] Yonsei Univ, Inst Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea

[5] Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea

来源：

CLINICAL AND MOLECULAR HEPATOLOGY | 2021年 / 27卷 / 03期

关键词：

Entecavir; Tenofovir; Hepatitis B; Carcinoma; Hepatocellular; Efficacy; Outcome; DISOPROXIL FUMARATE; RISK; CIRRHOSIS;

D O I：

10.3350/cmh.2021.0179

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Over the past several decades, entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have remained the first-line antiviral agents in several international guidelines. These two antiviral agents have shown similar short to intermediate-term efficacy, including virologic, biochemical, serologic, and histologic responses. However, huge controversies regarding the antiviral efficacy of ETV and TDF in preventing the development of hepatocellular carcinoma (HCC) still exist. In this review, we summarized recent studies that compared the treatment efficacy of ETV and TDF in terms of HCC development.

引用

页码：402 / 412

页数：11

共 44 条

[11] Impact of tenofovir antiviral treatment on survival of chronic hepatitis B related hepatocellular carcinoma after hepatectomy in Chinese individuals from Qingdao municipality [J].

Ge, Zhong ;

Ma, Jian ;

Qiao, Bing ;

Wang, Yanling ;

Zhang, Haifeng ;

Gou, Wei .

MEDICINE, 2020, 99 (32) :E21454

[12] Comparison of tenofovir versus entecavir on reducing incidence of hepatocellular carcinoma in chronic hepatitis B patients: A systematic review and meta-analysis [J].

Gu, Lihu ;

Yao, Qigu ;

Shen, Zefeng ;

He, Ying ;

Ng, Derry Minyao ;

Yang, Tong ;

Chen, Bangsheng ;

Chen, Ping ;

Mao, Feiyan ;

Yu, Qili .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020, 35 (09) :1467-1476

[13] Comparison of the on-treatment risks for hepatocellular carcinoma between entecavir and tenofovir: A propensity score matching analysis [J].

Ha, Ingyoon ;

Chung, Jung Wha ;

Jang, Eun Sun ;

Jeong, Sook-Hyang ;

Kim, Jin-Wook .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020, 35 (10) :1774-1781

[14] Hepatocellular carcinoma and death and transplantation in chronic hepatitis B treated with entecavir or tenofovir disoproxil fumarate [J].

Ha, Yeonjung ;

Chon, Young Eun ;

Kim, Mi Na ;

Lee, Joo Ho ;

Hwang, Seong Gyu .

SCIENTIFIC REPORTS, 2020, 10 (01)

[15] Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries [J].

Hou, Jin-Lin ;

Zhao, Wei ;

Lee, Changhyeong ;

Hann, Hie-Won ;

Peng, Cheng-Yuan ;

Tanwandee, Tawesak ;

Morozov, Viacheslav ;

Klinker, Hartwig ;

Sollano, Jose D. ;

Streinu-Cercel, Adrian ;

Cheinquer, Hugo ;

Xie, Qing ;

Wang, Yu-Ming ;

Wei, Lai ;

Jia, Ji-Dong ;

Gong, Guozhong ;

Han, Kwang-Hyub ;

Cao, Wukui ;

Cheng, Mingliang ;

Tang, Xiaoping ;

Tan, Deming ;

Ren, Hong ;

Duan, Zhongping ;

Tang, Hong ;

Gao, Zhiliang ;

Chen, Shijun ;

Lin, Shumei ;

Sheng, Jifang ;

Chen, Chengwei ;

Shang, Jia ;

Han, Tao ;

Ji, Yanyan ;

Niu, Junqi ;

Sun, Jian ;

Chen, Yongpeng ;

Cooney, Elizabeth L. ;

Lim, Seng-Gee .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (02) :457-+

[16] Tenofovir Versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B [J].

Hsu, Yao-Chun ;

Wong, Grace Lai-Hung ;

Chen, Chong ;

Peng, Cheng-Yuan ;

Yeh, Ming-Lun ;

Cheung, Ka-Shing ;

Toyoda, Hidenori ;

Huang, Chung-Feng ;

Huy Trinh ;

Xie, Qing ;

Enomoto, Masaru ;

Liu, Li ;

Yasuda, Satoshi ;

Tanaka, Yasuhito ;

Kozuka, Ritsuzo ;

Tsai, Pei-Chien ;

Huang, Yen-Tsung ;

Wong, Christopher ;

Huang, Rui ;

Jang, Tyng-Yuan ;

Hoang, Joseph ;

Yang, Hwai-, I ;

Li, Jiayi ;

Lee, Dong-Hyun ;

Takahashi, Hirokazu ;

Zhang, Jian Q. ;

Ogawa, Eiichi ;

Zhao, Changqing ;

Liu, Chenghai ;

Furusyo, Norihiro ;

Eguchi, Yuichiro ;

Wong, Clifford ;

Wu, Chao ;

Kumada, Takashi ;

Yuen, Man-Fung ;

Yu, Ming-Lung ;

Nguyen, Mindie H. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2020, 115 (02) :271-280

[17] HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B [J].

Kim, Beom Kyung ;

Revill, Peter A. ;

Ahn, Sang Hoon .

ANTIVIRAL THERAPY, 2011, 16 (08) :1169-1186

[18] Mortality, liver transplantation and hepatic complications in patients with treatment-naive chronic hepatitis B treated with entecavir vs tenofovir [J].

Kim, Byung Gyu ;

Park, Neung Hwa ;

Lee, Seung Bum ;

Lee, Hojune ;

Lee, Byung Uk ;

Park, Jae Ho ;

Jung, Seok Won ;

Jeong, In Du ;

Bang, Sung-Jo ;

Shin, Jung Woo .

JOURNAL OF VIRAL HEPATITIS, 2018, 25 (12) :1565-1575

[19] A multicenter study of entecavir vs. tenofovir on prognosis of treatment-naive chronic hepatitis B in South Korea [J].

Kim, Seung Up ;

Seo, Yeon Seok ;

Lee, Han Ah ;

Kim, Mi Na ;

Lee, Yu Rim ;

Lee, Hye Won ;

Park, Jun Yong ;

Kim, Do Young ;

Ahn, Sang Hoon ;

Han, Kwang-Hyub ;

Hwang, Seong Gyu ;

Rim, Kyu Sung ;

Um, Soon Ho ;

Tak, Won Young ;

Kweon, Young Oh ;

Kim, Beom Kyung ;

Park, Soo Young .

JOURNAL OF HEPATOLOGY, 2019, 71 (03) :456-464

[20]

Kim WR, 2019, HEPATOLOGY, V70, p302A

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