Taxanes from the bark of Taxus brevifolia

被引：12
|
作者：
Rao, KV [1 ]
Bhakuni, RS [1 ]
Hanuman, JB [1 ]
Davies, R [1 ]
Johnson, J [1 ]
机构：
[1] UNIV FLORIDA,COLL PHARM,DEPT MED CHEM,GAINESVILLE,FL 32610
来源：
PHYTOCHEMISTRY | 1996年 / 41卷 / 03期
关键词：
Taxus brevifolia; Taxaceae; yew bark; taxanes; paclitaxel; abeotaxane; 9-dihydrobaccatin III; baccatin IV; panosterone A;
D O I：
10.1016/0031-9422(95)00672-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Examination of the extracts of the bark of Taxus brevifolia showed the presence of two new crystalline taxanes: 10 beta-benzoyloxy-2 alpha,4 alpha-diacetoxy-5 beta,20-epoxy-1 beta,7 beta,9 alpha,13 alpha-tetrahydroxy-11(15-->1)-abeotaxane and 7,9-deacetyl baccatin IV, along with ponasterone A and three other crystalline taxanes: baccatin IV, 9-dihydro-13-acetyl baccatin III and 1 beta,7 beta-dihydroxy-4 beta,20-epoxy-2 alpha,5 alpha,9 alpha,10 beta,13 alpha-penta-acetoxy-tax-11-ene, isolated earlier from other species of Taxus.
引用
收藏
页码：863 / 866
页数：4
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