Assays of Serum Testosterone

被引:18
作者
Herati, Amin S. [1 ]
Cengiz, Cenk [1 ]
Lamb, Dolores J. [1 ,2 ]
机构
[1] Baylor Coll Med, Scott Dept Urol, Ctr Reprod Med, 1 Baylor Plaza,Suite N730, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol & Cellular Biol, 1 Baylor Plaza, Houston, TX 77030 USA
关键词
Adult; Humans; Testosterone/blood; Steroids/blood; Circadian rhythm; Hypogonadism/metabolism; Testosterone/deficiency; Immunoassay; TANDEM MASS-SPECTROMETRY; HORMONE-BINDING GLOBULIN; BIOAVAILABLE TESTOSTERONE; ANDROGEN DEFICIENCY; PLASMA TESTOSTERONE; BOUND TESTOSTERONE; NORMAL WOMEN; OLDER MEN; VALIDATION; DIHYDROTESTOSTERONE;
D O I
10.1016/j.ucl.2016.01.003
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The diagnosis of male hypogonadism depends on an assessment of the clinical signs and symptoms of hypogonadism and serum testosterone level. Current clinical laboratory testosterone assay platforms include immunoassays and mass spectrometry. Despite significant advances to improve the accuracy and precision of the currently available assays, limited comparability exists between assays at the lower and upper extremes of the testosterone range. Because of this lack of comparability, there is no current gold standard assay for the assessment of total testosterone levels.
引用
收藏
页码:177 / +
页数:9
相关论文
共 56 条
[21]   Editorial: Serum testosterone assays - Accuracy matters [J].
Matsumoto, AM ;
Bremner, WJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :520-524
[22]   Measurement of free testosterone in normal women and women with androgen deficiency: Comparison of methods [J].
Miller, KK ;
Rosner, W ;
Lee, H ;
Hier, J ;
Sesmilo, G ;
Schoenfeld, D ;
Neubauer, G ;
Klibanski, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :525-533
[23]   Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry.: Comparison with five immunoassay techniques [J].
Moal, Valerie ;
Mathieu, Elisabeth ;
Reynier, Pascal ;
Malthiery, Yves ;
Gallois, Yves .
CLINICA CHIMICA ACTA, 2007, 386 (1-2) :12-19
[24]   Evaluation of assays available to measure free testosterone [J].
Morley, JE ;
Patrick, P ;
Perry, HM .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (05) :554-559
[25]   Validation of a screening questionnaire for androgen deficiency in aging males [J].
Morley, JE ;
Charlton, E ;
Patrick, P ;
Kaiser, FE ;
Cadeau, P ;
McCready, D ;
Perry, HM .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (09) :1239-1242
[26]   Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone [J].
Morley, JE ;
Kaiser, F ;
Raum, WJ ;
Perry, HM ;
Flood, JF ;
Jensen, J ;
Silver, AJ ;
Roberts, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7537-7542
[27]   A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men [J].
Morris, PD ;
Malkin, CJ ;
Channer, KS ;
Jones, TH .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 151 (02) :241-249
[28]   DECREASED BIOAVAILABLE TESTOSTERONE IN AGING NORMAL AND IMPOTENT MEN [J].
NANKIN, HR ;
CALKINS, JH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (06) :1418-1420
[29]   The Laboratory Diagnosis of Testosterone Deficiency [J].
Paduch, Darius A. ;
Brannigan, Robert E. ;
Fuchs, Eugene F. ;
Kim, Edward D. ;
Marmar, Joel L. ;
Sandlow, Jay I. .
UROLOGY, 2014, 83 (05) :980-988
[30]  
PLYMATE SR, 1989, J ANDROL, V10, P366