ATM at the crossroads of reactive oxygen species and autophagy

被引：33

作者：

Xie, Xiaochen ^{[1
,2
]}

Zhang, Ye ^{[1
]}

Wang, Zhuo ^{[1
]}

Wang, Shanshan ^{[1
]}

Jiang, Xiaoyou ^{[1
]}

Cui, Hongyan ^{[1
]}

Zhou, Tingting ^{[1
]}

He, Zheng ^{[3
]}

Feng, Hao ^{[4
]}

Guo, Qiqiang ^{[1
]}

Song, Xiaoyu ^{[1
]}

Cao, Liu ^{[1
]}

机构：

[1] China Med Univ, Coll Basic Med Sci, Key Lab Med Cell Biol, Minist Educ,Key Lab Liaoning Prov, Shenyang 110122, Liaoning, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Inst Endocrinol, Dept Endocrinol & Metab,Liaoning Prov Key Lab End, Shenyang 110001, Liaoning, Peoples R China

[3] China Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China

[4] China Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2021年 / 17卷 / 12期

关键词：

ATM; ROS; oxidative stress; autophagy; DNA damage response; ATAXIA-TELANGIECTASIA GENE; DNA-DAMAGE RESPONSE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; CELLULAR SENESCENCE; ACTIVATES ATM; FREE-RADICALS; PROTEIN; ROS; GENERATION;

D O I：

10.7150/ijbs.63963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) are generally small, short-lived and highly reactive molecules, initially thought to be a pathological role in the cell. A growing amount of evidence in recent years argues for ROS functioning as a signaling intermediate to facilitate cellular adaptation in response to pathophysiological stress through the regulation of autophagy. Autophagy is an essential cellular process that plays a crucial role in recycling cellular components and damaged organelles to eliminate sources of ROS in response to various stress conditions. A large number of studies have shown that DNA damage response (DDR) transducer ataxia-telangiectasia mutated (ATM) protein can also be activated by ROS, and its downstream signaling pathway is involved in autophagy regulation. This review aims at providing novel insight into the regulatory mechanism of ATM activated by ROS and its molecular basis for inducing autophagy, and revealing a new function that ATM can not only maintain genome homeostasis in the nucleus, but also as a ROS sensor trigger autophagy to maintain cellular homeostasis in the cytoplasm.

引用

页码：3080 / 3090

页数：11

共 106 条

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