The synthesis of the high-potency sweetener, NC-00637.: part 1:: The synthesis of (S)-2-methylhexanoic acid

被引：12

作者：

Ager, DJ ^{[1
]}

Babler, S ^{[1
]}

Froen, DE ^{[1
]}

Laneman, SA ^{[1
]}

Pantaleone, DP ^{[1
]}

Prakash, I ^{[1
]}

Zhi, B ^{[1
]}

机构：

[1] NutraSweet R&D, Mt Prospect, IL 60056 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 03期

关键词：

D O I：

10.1021/op025616i

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of the high potency sweetener candidate NC-00637 (1) required large quantities of (S)-2-methylhexanoic acid (2). This acid was first prepared in small quantities by the use of chiral auxiliaries. For large quantities, resolution by classical means and an enzymatic method were investigated. Asymmetric hydrogenation provided a workable solution.

引用

页码：369 / 378

页数：10

共 36 条

[1] 1,2-amino alcohols and their heterocyclic derivatives as chiral auxiliaries in asymmetric synthesis [J].