Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line

被引：26
作者：
Cimmino, Flora [1 ]
Spano, Daniela [1 ]
Capasso, Mario [1 ]
Zambrano, Nicola [1 ]
Russo, Roberta [1 ]
Zollo, Massimo [1 ]
Iolascon, Achille [1 ]
机构：
[1] Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, Ctr Ingn Genet CEINGE Biotecnol Avanzate, I-80145 Naples, Italy
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 07期
关键词：
neuroblastoma; all-trans-retinoic acid; 2D-DIGE; LAN-5 human neuroblastoma cell line;
D O I：
10.1021/pr060701g
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta 2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.
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收藏
页码：2550 / 2564
页数：15
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