An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions

被引：57

作者：

Hitomi, Kaori ^{[1
]}

Tahara-Hanaoka, Satoko ^{[1
]}

Someya, Satoru ^{[1
]}

Fujiki, Akira ^{[2
]}

Tada, Hideaki ^{[2
]}

Sugiyama, Tetsuya ^{[2
]}

Shibayama, Shiro ^{[2
]}

Shibuya, Kazuko ^{[1
]}

Shibuya, Akira ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Immunol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 305, Japan

[2] Tsukuba Res Inst, Exploratory Res Labs, Tsukuba, Ibaraki, Japan

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 07期

关键词：

MAST-CELL ACTIVATION; FC-EPSILON-RI; SYSTEMIC-ANAPHYLAXIS; NEGATIVE REGULATION; BASOPHILS PLAY; GAMMA RIII; IGE; IDENTIFICATION; DEGRANULATION; MOTIFS;

D O I：

10.1038/ni.1886

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anaphylaxis is a life-threatening immediate hypersensitivity reaction triggered by antigen capture by immunoglobulin E (IgE) bound to the high-affinity IgE receptor (Fc epsilon RI) on mast cells. However, the regulatory mechanism of mast cell activation is not completely understood. Here we identify an immunoglobulin-like receptor, Allergin-1, that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM)-like domain, and show it was preferentially expressed on mast cells. Mouse Allergin-1 recruited the tyrosine phosphatases SHP-1 and SHP-2 and the inositol phosphatase SHIP. Coligation of Allergin-1 and FceRI suppressed IgE-mediated degranulation of bone marrow-derived cultured mast cells. Moreover, mice deficient in Allergin-1 developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice.

引用

页码：601 / U61

页数：8

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