Infusion of Donor Lymphocytes Genetically Engineered to Express the Herpes Simplex Virus Thymidine Kinase (HSV-TK) Suicide Gene after Haploidentical Hematopoietic Stem Cell Transplantation (HSCT): Preliminary Efficacy Data from the Randomized TK008 Study

被引：0

作者：

Bonini, Chiara ^{[1
]}

Ciceri, Fabio ^{[2
]}

Nagler, Arnon ^{[3
]}

Yannaki, Evangelia ^{[4
]}

Stanghellini, Maria Teresa Lupo ^{[5
]}

Oliveira, Giacomo ^{[2
]}

Bondanza, Attilio ^{[5
,6
]}

Vago, Luca ^{[5
]}

Greco, Raffaella ^{[2
]}

Peccatori, Jacopo ^{[5
]}

Olovarria, Eduardo ^{[7
]}

Mischak-Weissinger, Eva M. ^{[8
]}

Stadler, Michael ^{[9
]}

Bunjes, Donald ^{[10
]}

Niederwieser, Dietger ^{[11
]}

Uharek, Lutz ^{[12
]}

Bethge, Wolfgang A. ^{[13
]}

DiPersio, John F. ^{[14
]}

Donato, Michele L. ^{[15
]}

Pecora, Andrew L. ^{[16
]}

Colombi, Scialini ^{[17
]}

Antonio, Lambiase ^{[17
]}

Bordignon, Claudio ^{[17
,18
]}

机构：

[1] Ist Sci San Raffaele, Expt Hematol Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, I-20132 Milan, Italy

[3] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel

[4] George Papanicolaou Hosp, Thessaloniki, Greece

[5] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy

[6] Ist Sci San Raffaele, Expt Hematol Unit, Div Regenerat Med Stem Cells & Gene Therapy, I-20132 Milan, Italy

[7] Complejo Hosp Navarra, Pamplona, Spain

[8] Hannover Med Sch, Hannover, Germany

[9] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[10] Univ Ulm, D-89069 Ulm, Germany

[11] Univ Hosp Leipzig, Leipzig, Germany

[12] Charite, Univ Hosp Berlin, Berlin, Germany

[13] Univ Tubingen, Tubingen, Germany

[14] Washington Univ, Sch Med, St Louis, MO USA

[15] Hackensack Univ, Med Ctr, Hackensack, NJ USA

[16] Hackensack Univ, Med Ctr, John Theurer Canc Ctr, Hackensack, NJ USA

[17] MolMed, Milan, Italy

[18] Univ Vita Salute San Raffaele, Milan, Italy

来源：

BLOOD | 2014年 / 124卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 17 条

[1] Efficacy of HSV-TK+ suicide gene donor lymphocytes after haploidentical transplantation (haplo-HSCT): Preliminary results of randomized TK008 study.
Ciceri, Fabio
Bonini, Chiara
Nagler, Ameon
Yannaki, Evangelia
Stanghellini, Maria Teresa Lupo
Bondanza, Attilio
Oliveira, Giacomo
Greco, Raffaella
Olavarria, Eduardo
Weissinger, Eva M.
Stadler, Michael
Bunjes, Donald
Niederwieser, Dietger
Uharek, Lutz
Bethge, Wolfgang
DiPersio, John
Donato, Michele
Pecora, Andrew
Lambiase, Antonio
Bordignon, Claudio
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[2] Infusion of HSV-Tk engineered donor lymphocytes provide early immune reconstitution and abrogation of GvHD after haploidentical hemopoietic stem cell transplantation.
Ciceri, F
Bonini, C
Bondanza, A
Magnani, Z
Bernardi, M
Peccatori, J
Crippa, F
Stampino, CG
Bregni, M
Bordignon, C
Raffaele, HS
BLOOD CELLS MOLECULES AND DISEASES, 2004, 33 (03) : 180 - 181
[3] Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Hashimoto, Hisayoshi
Kitano, Shigehisa
Ueda, Ryosuke
Ito, Ayumu
Tada, Kohei
Fuji, Shigeo
Yamashita, Takuya
Tomura, Daisuke
Nukaya, Ikuei
Mineno, Junichi
Fukuda, Takahiro
Mori, Shinichiro
Takaue, Yoichi
Heike, Yuji
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2015, 102 (01) : 101 - 110
[4] Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Hisayoshi Hashimoto
Shigehisa Kitano
Ryosuke Ueda
Ayumu Ito
Kohei Tada
Shigeo Fuji
Takuya Yamashita
Daisuke Tomura
Ikuei Nukaya
Junichi Mineno
Takahiro Fukuda
Shinichiro Mori
Yoichi Takaue
Yuji Heike
International Journal of Hematology, 2015, 102 : 101 - 110
[5] Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Hisayoshi Hashimoto
Shigehisa Kitano
Ryosuke Ueda
Ayumu Ito
Kohei Tada
Shigeo Fuji
Sung-Won Kim
Takuya Yamashita
Daisuke Tomura
Ikuei Nukaya
Junichi Mineno
Takahiro Fukuda
Shinichiro Mori
Yoichi Takaue
Yuji Heike
International Journal of Hematology, 2015, 102 : 506 - 506
[6] Abrogation of GvHD and early immune reconstitution after infusion of HSV-TK engineered donor lymphocytes after haplo-identical hemopoietic stem cell transplantation.
Bonini, C
Ciceri, F
Marktel, S
Magnani, Z
Cazzaniga, S
Zappone, E
Servida, P
Pescarollo, A
Callegaro, L
Bernardi, M
Bregni, M
Bordignon, C
BLOOD, 2002, 100 (11) : 115A - 115A
[7] Early immune reconstitution and abrogation of GvHD after infusion of HSV-TK engineered donor lymphocytes after haplo-identical hemopoietic stem cell transplantation.
Ciceri, F
Bonini, C
Bondanza, A
Magnani, Z
Bernardi, M
Peccatori, J
Crippa, F
Stampino, CG
Bregni, M
Bordignon, C
Raffaele, HS
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) : 561S - 561S
[8] Safety and Efficacy of Donor T Cells Engineered with Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK Cells) Given after T-Cell Depleted (TCD) Haploidentical Hematopoietic Transplantation (Haplo-HSCT): Results of a 14-Year Follow-Up in 45 Patients
Ciceri, Fabio
Bonini, Chiara
Labopin, Myriam
Oliveira, Giacomo
Nagler, Arnon
Yannaki, Evangelia
Stanghellini, Maria Teresa Lupo
Bondanza, Attilio
Greco, Raffaella
Olavarria, Eduardo
Weissinger, Eva
Stadler, Michael
Bunjes, Donald
Niederwieser, Dietger
Uharek, Lutz
Bethge, Wolfgang
DiPersio, John
Pecora, Andrew L.
Donato, Michele
Colombi, Scialini
Lambiase, Antonio
Bordignon, Claudio
Mohty, Mohamad
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (03) : S39 - S40
[9] Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation (vol 102, pg 101, 2015)
Hashimoto, Hisayoshi
Kitano, Shigehisa
Ueda, Ryosuke
Ito, Ayumu
Tada, Kohei
Fuji, Shigeo
Kim, Sung-Won
Yamashita, Takuya
Tomura, Daisuke
Nukaya, Ikuei
Mineno, Junichi
Fukuda, Takahiro
Mori, Shinichiro
Takaue, Yoichi
Heike, Yuji
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2015, 102 (04) : 506 - 506
[10] Impact of Immune Reconstitution (IR) and Graft-Versus-Host Disease (GvHD) on Clinical Outcomes after Treatment with Donor T Cells Transduced to Express the Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK cells) in Acute Leukemia Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)
Ciceri, Fabio
Bonini, Chiara
Nagler, Arnon
Yannaki, Evangelia
Stanghellini, Maria Teresa Lupo
Bondanza, Attilio
Greco, Raffaella
Olovarria, Eduardo
Mischak-Weissinger, Eva M.
Stadler, Michael
Bunjes, Donald W.
Niederwieser, Dietger
Uharek, Lutz
Betghe, Wolfgang
DiPersio, John F.
Donato, Michele L.
Pecora, Andrew L.
Colombi, Scialini
Lambiase, Antonio
Bordignon, Claudio
BLOOD, 2016, 128 (22)

← 1 2 →