Prospects of viral vector-mediated delivery of sequences encoding anti-HBV designer endonucleases
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作者:
Jacobs, Ridhwaanah
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Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Jacobs, Ridhwaanah
[1
]
Singh, Prashika
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Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Singh, Prashika
[1
]
Smith, Tiffany
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Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Smith, Tiffany
[1
]
Arbuthnot, Patrick
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Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Arbuthnot, Patrick
[1
]
Maepa, Mohube Betty
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Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South AfricaUniv Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Maepa, Mohube Betty
[1
]
机构:
[1] Univ Witwatersrand, Fac Hlth Sci, Wits SAMRC Antiviral Gene Therapy Res Unit, Johannesburg, South Africa
Available treatment for chronic hepatitis B virus (HBV) infection offers modest functional curative efficacy. The viral replicative intermediate comprising covalently closed circular DNA (cccDNA) is responsible for persistent chronic HBV infection. Hence, current efforts have focused on developing therapies that disable cccDNA. Employing gene editing tools has emerged as an attractive strategy, with the end goal of establishing permanently inactivated cccDNA. Although anti-HBV designer nucleases are effective in vivo, none has yet progressed to clinical trial. Lack of safe and efficient delivery systems remains the limiting factor. Several vectors may be used to deliver anti-HBV gene editor-encoding sequences, with viral vectors being at the forefront. Despite the challenges associated with packaging large gene editor-encoding sequences into viral vectors, advancement in the field is overcoming such limitations. Translation of viral vector-mediated gene editing against HBV to clinical application is within reach. This review discusses the prospects of delivering HBV targeted designer nucleases using viral vectors.
机构:
Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Maepa, Mohube Betty
Bloom, Kristie
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Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Bloom, Kristie
Ely, Abdullah
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Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Ely, Abdullah
Arbuthnot, Patrick
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Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
机构:
Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Mendonca, Samir Andrade
Lorincz, Reka
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Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Lorincz, Reka
Boucher, Paul
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Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Boucher, Paul
Curiel, David T.
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Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Metzger, Michael J.
McConnell-Smith, Audrey
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Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA
Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
McConnell-Smith, Audrey
Stoddard, Barry L.
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Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Stoddard, Barry L.
Miller, A. Dusty
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Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
机构:
Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Maepa, Mohube Betty
Bloom, Kristie
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Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Bloom, Kristie
Ely, Abdullah
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Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
Ely, Abdullah
Arbuthnot, Patrick
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机构:
Univ Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South AfricaUniv Witwatersrand, Wits SAMRC Antiviral Gene Therapy Res Unit, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa
机构:
Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Mendonca, Samir Andrade
Lorincz, Reka
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Lorincz, Reka
Boucher, Paul
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h-index: 0
机构:
Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
Boucher, Paul
Curiel, David T.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USAWashington Univ, Sch Med, Biol Therapeut Ctr, Radiat Oncol Dept, 660 South Euclid Ave, St Louis, MO 63110 USA
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Metzger, Michael J.
McConnell-Smith, Audrey
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA
Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
McConnell-Smith, Audrey
Stoddard, Barry L.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Stoddard, Barry L.
Miller, A. Dusty
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA