Complementing asthma

被引:16
作者
Henson, P [1 ]
机构
[1] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA
关键词
D O I
10.1038/79723
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The complement inflammatory cascade is crucial to our innate ability to ward off infection. Two papers now provide evidence linking C5 and C3a to murine airway hyperresponsiveness, a partial model of human asthma. Surprisingly, these complement proteins appear to have opposite effects.
引用
收藏
页码:190 / 192
页数:3
相关论文
共 9 条
[1]   INCREASED LOWER AIRWAYS RESPONSIVENESS ASSOCIATED WITH SINUSITIS IN A RABBIT MODEL [J].
BRUGMAN, SM ;
LARSEN, GL ;
HENSON, PM ;
HONOR, J ;
IRVIN, CG .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (02) :314-320
[2]   The C5a chemoattractant receptor mediates mucosal defence to infection [J].
Hopken, UE ;
Lu, B ;
Gerard, NP ;
Gerard, C .
NATURE, 1996, 383 (6595) :86-89
[3]  
HUMBLES AA, 2000, IN PRESS NATURE, P406
[4]  
IRVIN CG, 1986, AM REV RESPIR DIS, V134, P777
[5]   Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma [J].
Karp, CL ;
Grupe, A ;
Schadt, E ;
Ewart, SL ;
Keane-Moore, M ;
Cuomo, PJ ;
Köhl, J ;
Wahl, L ;
Kuperman, D ;
Germer, S ;
Aud, D ;
Peltz, G ;
Wills-Karp, M .
NATURE IMMUNOLOGY, 2000, 1 (03) :221-226
[6]   Regulation of interleukin-12 by complement receptor 3 signaling [J].
Marth, T ;
Kelsall, BL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (11) :1987-1995
[7]   Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig [J].
Regal, JF ;
Klos, A .
IMMUNOPHARMACOLOGY, 2000, 46 (01) :15-28
[8]   Selective suppression of interleukin-12 induction after macrophage receptor ligation [J].
Sutterwala, FS ;
Noel, GJ ;
Clynes, R ;
Mosser, DM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (11) :1977-1985
[9]  
Teran LM, 1997, CLIN EXP ALLERGY, V27, P396