The current study examined the main and interaction effects of leisure self-determination and two leisure social support types (emotional and instrumental) on stress in nursing home residents. A total of 139 nursing home residents (mean age = 79.4 years) in Taichung City, Taiwan, were recruited. Data were collected using face-to-face surveys, which included measures of leisure self-determination, leisure emotional support, leisure instrumental support, and stress. Data were analyzed using a hierarchical regression analysis. Results indicated that leisure self-determination and leisure emotional support were significantly and negatively correlated with stress, whereas leisure instrumental support was not. Moreover, higher levels of leisure instrumental support decreased the relationship between leisure self-determination and stress reduction. Therefore, enhancing levels of leisure self-determination and leisure emotional support appears to be an effective means of reducing stress in nursing home residents. However, providing excessive leisure instrumental support to nursing home residents should be avoided.