Photodynamic Therapy: Current Status and Future Directions

被引：309
作者：
Benov, Ludmil [1 ]
机构：
[1] Kuwait Univ, Fac Med, Hlth Sci Ctr, Dept Biochem, Jabriya, Kuwait
来源：
MEDICAL PRINCIPLES AND PRACTICE | 2015年 / 24卷
关键词：
Photodynamic therapy; Photosensitizer; orphyrin; Singlet oxygen; Hydroxyl radical; Superoxide; STABLE SYNTHETIC BACTERIOCHLORINS; SINGLET OXYGEN; LIPID-PEROXIDATION; IN-VITRO; N-ALKYLPYRIDYLPORPHYRINS; PHOTO-TREATMENT; CENTRAL METAL; DAMAGE; PHOTOSENSITIZERS; SUPEROXIDE;
D O I：
10.1159/000362416
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Photodynamic therapy (PDT) is a minimally invasive therapeutic modality used for the management of a variety of cancers and benign diseases. The destruction of unwanted cells and tissues in PDT is achieved by the use of visible or near-infrared radiation to activate a light-absorbing compound (a photosensitizer, PS), which, in the presence of molecular oxygen, leads to the production of singlet oxygen and other reactive oxygen species. These cytotoxic species damage and kill target cells. The development of new PSs with properties optimized for PDT applications is crucial for the improvement of the therapeutic outcome. This review outlines the principles of PDT and discusses the relationship between the structure and physicochemical properties of a PS, its cellular uptake and subcellular localization, and its effect on PDT outcome and efficacy. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：14 / 28
页数：15
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