Synthesis of N-(trimethylsilylethoxycarbonyl)-deoxycytidine and deoxy-adenosine derivatives as key intermediates for the DNA synthesis using fluoride ion-promoted deprotection strategy

被引：5

作者：

Sekine, M ^{[1
]}

Tobe, M ^{[1
]}

Nagayama, T ^{[1
]}

Wada, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Japan Sci & Technol Agcy, JST, CREST, Yokohama, Kanagawa 2268501, Japan

来源：

LETTERS IN ORGANIC CHEMISTRY | 2004年 / 1卷 / 02期

关键词：

Teoc group; base-sensitive; N-protected nucleosides; DNA/RNA chemical synthesis; protecting group;

D O I：

10.2174/1570178043488419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the synthesis of trimethylsilylethyl chloroformate (Teoc-Cl) was studied in great detail. N-Teoc-adenosine. X-Teoc-cytidine and their deoxyribonucleoside derivatives were synthesized as the key synthetic intermediates for the synthesis of base-sensitive oligonucleotide derivatives by use of N-methylimidazole. The stability and chemical properties of these N-protected nucleoside derivatives were examined.

引用

页码：179 / 182

页数：4

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