Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice

被引:25
作者
Huang, Chao [1 ,2 ,3 ]
Wang, Jian [1 ,2 ,3 ]
Zheng, Xiaodong [1 ,2 ,3 ]
Chen, Yongyan [1 ,2 ,3 ]
Zhou, Rongbin [1 ,2 ,3 ,4 ]
Wei, Haiming [1 ,2 ,3 ,4 ]
Sun, Rui [1 ,2 ,3 ,4 ]
Tian, Zhigang [1 ,2 ,3 ,4 ]
机构
[1] Univ Sci & Technol China, Inst Immunol, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China
[3] Univ Sci & Technol China, Med Ctr, Hefei 230027, Anhui, Peoples R China
[4] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
Allergic asthma; Commensal bacteria; NLRP3/IL-1 beta signaling; Post-weaning mice; EARLY-LIFE; AIRWAY INFLAMMATION; NLRP3; INFLAMMASOME; HYGIENE HYPOTHESIS; IMMUNE-SYSTEM; COLONIZATION; MICROBIOTA; MACROPHAGES; SUPPRESSION; DYSBIOSIS;
D O I
10.1016/j.jaut.2018.07.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Perturbation of commensal bacteria by antibiotic exposure aggravates ovalbumin (OVA)-induced allergic asthma in pre-weaning mice. However, the influence of dysbiosis of commensal bacteria on asthma development in post weaning mice is still limited. Here, we treated 3-week-old post-weaning mice with antibiotics to disrupt corn mensal bacteria and then established OVA-induced allergic asthma by peritoneal sensitization using OVA/alum and intranasal challenge with OVA. Contrary to the protective function in pre-weaning mice, commensal bacteria in post-weaning mice aggravated OVA-induced asthma. Commensal bacteria in post-weaning mice promoted OVA-induced allergic asthma through maintenance of NLRP3/IL-1 beta expression in peritoneal macrophages (pM phi), which promoted recruitment of inflammatory cells, especially inflammatory monocytes, into the peritoneal cavity after OVA/alum sensitization. Further study showed that metronidazole- and vancomycin-sensitive bacteria are involved in maintenance of NLRP3/IL-1 beta signal in pM phi. Our results suggest that certain species of commensal bacteria in post-weaning mice aggravate OVA-induced allergic asthma through NLRP3/IL-1 beta signal pathway.
引用
收藏
页码:104 / 113
页数:10
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