Metabolic remodeling induced by mitokines in heart failure

被引：12

作者：

Duan, Jiahao ^{[1
]}

Chen, Zijun ^{[1
]}

Wu, Yeshun ^{[1
]}

Zhu, Bin ^{[2
]}

Yang, Ling ^{[1
]}

Yang, Chun ^{[3
]}

机构：

[1] Soochow Univ, Dept Cardiol, Affiliated Hosp 3, Changzhou 213003, Peoples R China

[2] Soochow Univ, Dept Crit Care Med, Affiliated Hosp 3, Changzhou 213003, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430030, Hubei, Peoples R China

来源：

AGING-US | 2019年 / 11卷 / 17期

基金：

中国国家自然科学基金;

关键词：

heart; metabolism; mitohormesis; peptides; retrograde signaling; GROWTH-FACTOR; 21; UNFOLDED PROTEIN RESPONSE; BODY-MASS INDEX; DIFFERENTIATION FACTOR 15; INDUCED CARDIAC-HYPERTROPHY; BETA-KLOTHO EXPRESSION; OXIDATIVE STRESS; MOTS-C; ENERGY-METABOLISM; DOWN-REGULATION;

D O I：

10.18632/aging.102247

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prevalence rates of heart failure (HF) are greater than 10% in individuals aged >75 years, indicating an intrinsic link between aging and HF. It has been recognized that mitochondria! dysfunction contributes to the pathology of HF. Mitokines are a type of cytokines, peptides, or signaling pathways produced or activated by the nucleus or the mitochondria through cell non-autonomous responses during cellular stress. In addition to promoting the communication between the mitochondria and the nucleus, mitokines also exert a systemic regulatory effect by circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related HF risk factors and are associated with HF severity. Consequently, mitokines might represent a potential therapy target for HF.

引用

页码：7307 / 7327

页数：21

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