Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

被引：32

作者：

Alcaide, Maria L. ^{[1
]}

Ramlagan, Shandir ^{[2
]}

Rodriguez, Violeta J. ^{[3
]}

Cook, Ryan ^{[3
,4
]}

Peltzer, Karl ^{[2
,5
,6
]}

Weiss, Stephen M. ^{[3
]}

Sifunda, Sibusiso ^{[2
]}

Jones, Deborah L. ^{[3
]}

机构：

[1] Univ Miami, Div Infect Dis, Dept Med, Miller Sch Med, 1120 NW 14 St,CRB 864 D-90A, Miami, FL 33136 USA

[2] Human Sci Res Council, HIV AIDS STIs & TB HAST Res Programme, Pretoria, South Africa

[3] Univ Miami, Dept Psychiat & Behav Sci, Miller Sch Med, 1120 NW 14 St,CRB 864 D-90A, Miami, FL 33136 USA

[4] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

[5] Mahidol Univ, ASEAN Inst Hlth Dev, Salaya, Nakhon Pathom, Thailand

[6] Univ Limpopo, Dept Res & Innovat, Sovenga, South Africa

来源：

AIDS AND BEHAVIOR | 2017年 / 21卷 / 07期

关键词：

Adherence; Women; HIV; South Africa; Antiretrovirals; Measurement; TO-CHILD TRANSMISSION; PREEXPOSURE PROPHYLAXIS; HIV; PREVENTION; TENOFOVIR; THERAPY; SCALE;

D O I：

10.1007/s10461-017-1760-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

引用

页码：2135 / 2140

页数：6

共 12 条

[1]

[Anonymous], 2011 NAT ANT SENT HI

[2]

Bangsberg D.R., 2001, AIDS BEHAV, V5, P275, DOI [DOI 10.1023/A:1011396711486, https://doi.org/10.1023/A:1011396711486]

[3] Determinants of male involvement in the prevention of mother-to-child transmission of HIV programme in Eastern Uganda: a cross-sectional survey [J].

Byamugisha, Robert ;

Tumwine, James K. ;

Semiyaga, Nulu ;

Tylleskaer, Thorkild .

REPRODUCTIVE HEALTH, 2010, 7

[4]

Castillo-Mancilla JR, 2015, AIDS RES HUM RETROV, V31, P428, DOI [10.1089/AID.2014.0229, 10.1089/aid.2014.0229]

[5] Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG Adherence Instruments [J].

Chesney, MA ;

Ickovics, JR ;

Chambers, DB ;

Gifford, AL ;

Neidig, J ;

Zwickl, B ;

Wu, AW .

AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2000, 12 (03) :255-266

[6] Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale [J].

Giordano, TP ;

Guzman, D ;

Clark, R ;

Charlebois, ED ;

Bangsberg, DR .

HIV CLINICAL TRIALS, 2004, 5 (02) :74-79

[7] Tenofovir, Emtricitabine Intracellular and Plasma, and Efavirenz Plasma Concentration Decay Following Drug Intake Cessation: Implications for HIV Treatment and Prevention [J].

Jackson, Akil ;

Moyle, Graeme ;

Watson, Victoria ;

Tjia, John ;

Ammara, Alieu ;

Back, David ;

Mohabeer, Malika ;

Gazzard, Brian ;

Boffito, Marta .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2013, 62 (03) :275-281

[8] Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial [J].

Jones, Deborah ;

Peltzer, Karl ;

Weiss, Stephen M. ;

Sifunda, Sibusiso ;

Dwane, Ntabozuko ;

Ramlagan, Shandir ;

Cook, Ryan ;

Matseke, Gladys ;

Maduna, Vincent ;

Spence, Andrew .

TRIALS, 2014, 15

[9]

Kalichman S, 2010, ANN BEHAV MED, V39, P85

[10] Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis [J].

Nachega, Jean B. ;

Uthman, Olalekan A. ;

Anderson, Jean ;

Peltzer, Karl ;

Wampold, Sarah ;

Cotton, Mark F. ;

Mills, Edward J. ;

Ho, Yuh-Shan ;

Stringer, Jeffrey S. A. ;

McIntyre, James A. ;

Mofenson, Lynne M. .

AIDS, 2012, 26 (16) :2039-2052

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