A quinoline-based Cu2+ ion complex fluorescence probe for selective detection of inorganic phosphate anion in aqueous solution and its application to living cells

被引：33

作者：

Dai, Yanpeng ^{[1
]}

Wang, Peng ^{[1
]}

Fu, Jiaxin ^{[1
]}

Yao, Kun ^{[1
]}

Xu, Kuoxi ^{[1
,2
]}

Pang, Xiaobin ^{[3
]}

机构：

[1] Henan Univ, Coll Chem & Chem Engn, Engn Lab Flame Retardant & Funct Mat Hennan Prov, Kaifeng 475004, Peoples R China

[2] Henan Univ, Inst Environm & Analyt Sci, Kaifeng 475004, Henan, Peoples R China

[3] Henan Univ, Inst Pharm, Kaifeng 475004, Henan, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2017年 / 183卷

基金：

中国国家自然科学基金;

关键词：

Fluorescence probe; Cu2+ ion detection; Complex; Phosphate sensing; SENSOR; RECOGNITION; FE3+; ENZYME; WATER; ASSAY;

D O I：

10.1016/j.saa.2017.04.015

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A quinaldine functionalized probe QP has been designed and synthesized. It exhibited selective turn-off fluorescence response toward Cu2+ ion over most of the biologically important ions at physiological pH. The binding ratio of the probe QP-and Cu2+ ion was determined to be 1:1 through fluorescence titration, Job's plot and ESIMS. The binding constant (K) of Cu2+ to probe QP was found to be 2.12 x 10(4) M-1. Further, the Cu2+ ensemble of probe QP was found to respond H2PO4 and HPO42- among other important biological anions via fluorescence turn-on response at physiological pH. Fluorescence microscopy imaging using living Hela cells showed that probe QP could be used as an effective fluorescent probe for detecting Cu2+ cation and H2PO4 and HPO42- anions in living cells. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：30 / 36

页数：7

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