Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer's disease

被引：18

作者：

Bu, Xian-Le ^{[1
,2
,3
,4
]}

Sun, Pu-Yang ^{[1
,2
,4
]}

Fan, Dong-Yu ^{[1
,2
,4
,5
]}

Wang, Jun ^{[1
,2
,4
]}

Sun, Hao-Lun ^{[5
]}

Cheng, Yuan ^{[1
,2
,4
]}

Zeng, Gui-Hua ^{[1
,2
,4
]}

Chen, Dong-Wan ^{[1
,2
,4
]}

Li, Hui-Yun ^{[1
,2
,4
]}

Yi, Xu ^{[1
,2
,4
]}

Shen, Ying-Ying ^{[1
,2
,4
]}

Miles, Luke A. ^{[6
]}

Maruff, Paul ^{[6
,7
]}

Gu, Ben J. ^{[6
]}

Fowler, Christopher J. ^{[6
]}

Masters, Colin L. ^{[6
]}

Wang, Yan-Jiang ^{[1
,2
,3
,4
,8
,9
]}

机构：

[1] Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing, Peoples R China

[2] Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing, Peoples R China

[3] Third Mil Med Univ, Inst Brain & Intelligence, Chongqing, Peoples R China

[4] Chongqing Key Lab Ageing & Brain Dis, Chongqing, Peoples R China

[5] Third Mil Med Univ, Xinqiao Hosp, Shigatse Branch, Shigatse, Peoples R China

[6] Univ Melbourne, Florey Inst, Victoria, Australia

[7] CogState, Melbourne, Vic, Australia

[8] Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China

[9] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China

来源：

SCIENCE ADVANCES | 2022年 / 8卷 / 13期

基金：

国家重点研发计划; 中国国家自然科学基金; 英国医学研究理事会;

关键词：

DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MICROGLIA; RECOMMENDATIONS; INDIVIDUALS; WORKGROUPS; EXPRESSION; IMMUNE;

D O I：

10.1126/sciadv.abm5667

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD22 has been suggested to contribute to Alzheimer's disease (AD) pathogenesis by inhibiting microglial amyloid beta (A beta) phagocytosis. Soluble CD22 (sCD22) generated by cleavage from cell membranes may be a marker of inflammation and microglial dysfunction; but alterations of sCD22 levels in AD and their correlation with AD biomarkers remain unclear. Plasma sCD22 levels were measured in cognitively normal non-AD participants and patients with preclinical AD and AD dementia from a Chinese cohort and the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Plasma sCD22 levels were elevated in patients with preclinical and dementia AD. Plasma sCD22 levels were negatively correlated with cerebrospinal fluid (CSF) A beta 42 levels and A beta 42/A beta 40, and positively correlated with CSF phosphorylated tau levels and brain A. burden, but negatively correlated with cognitive function. Moreover, higher plasma sCD22 levels were associated with faster cognitive decline during follow-up. These findings suggest that CD22 plays important roles in AD development, and that sCD22 is a potential biomarker for AD.

引用

页数：7

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