Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

被引：45

作者：

Huang, Ri-Ming ^{[1
,2
]}

Chen, Yin-Ning ^{[3
]}

Zeng, Ziyu ^{[4
]}

Gao, Cheng-Hai ^{[5
]}

Su, Xiangdong ^{[2
]}

Peng, Yan ^{[6
]}

机构：

[1] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

[2] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

[3] Guangxi Univ, Coll Light Ind & Food Engn, Nanning 530004, Peoples R China

[4] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[5] Guangxi Acad Sci, Key Lab Marine Environm Sci, Nanning 530007, Peoples R China

[6] Lingnan Normal Univ, Life Sci & Technol Sch, Zhanjiang 52048, Peoples R China

来源：

MARINE DRUGS | 2014年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

biological activity; biosynthetic pathway; marine organism; nucleoside; synthesis; POTENTIAL ANTICANCER AGENTS; 1ST NATURAL OCCURRENCE; PHARMACOLOGICAL-PROPERTIES; ADENINE-ARABINOSIDE; PURINE NUCLEOSIDES; SPONGE; ADENOSINE; PRODUCTS; ANALOGS; 1-METHYLISOGUANOSINE;

D O I：

10.3390/md12125817

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes. Some of these nucleosides have been obtained from a variety of marine resources. Because of the biological importance of these compounds, this review covers 68 marine originated nucleosides and their synthetic analogs published up to June 2014. The review will focus on the structures, bioactivities, synthesis and biosynthetic processes of these compounds.

引用

页码：5817 / 5838

页数：22

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