Evaluation of serum levels of interleukin-6 and interleukin-8 in patients with recurrent aphthous ulcerations

被引：0

作者：

Bakhtiari, Behnoush ^{[1
]}

Vaziri, Pejman Bakianian ^{[1
]}

Hajilooi, Mehrdad ^{[2
]}

Mortazavi, Hamed ^{[1
]}

机构：

[1] Hamedan Univ Med Sci, Sch Dent, Dept Oral Med, Hamadan, Iran

[2] Hamedan Univ Med Sci, Sch Dent, Res Ctr, Hamadan, Iran

来源：

HEALTHMED | 2010年 / 4卷 / 03期

关键词：

Interleukin-8; Interleukin-6; Recurrent aphthous ulcers; TUMOR-NECROSIS-FACTOR; ADAMANTIADES-BEHCETS-DISEASE; CHINESE MEDICINAL HERBS; ORAL LICHEN-PLANUS; FACTOR-ALPHA; ULCERS ROU; STOMATITIS; LEVAMISOLE; MARKER; CELLS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Recurrent aphthous ulcers (RAU) are one of the most common ulcers in oral cavity. Several studies have shown conflicting variations for inflammatory cytokines and other biologic markers in RAU. Aim: The aim of the present study was to determine the level of IL-8 and IL-6 in the serum of patients with RAU. Materials and method: In this case-control study, serum levels of IL-8 and IL-6 levels were measured in patients with RAU (n=40) and in healthy control subjects (n=40). The cytokines levels were measured in serum by ELISA. The SPSS software was used to analyze the results. Results: The mean value of IL-8 and IL-6 in patients (52.24 pg/ml and 9.39) was 10 and 4 fold higher than control group (5.01 pg/ml and 2.09 pg/ml), respectively. The difference was statistically significant (t-test p=0.01). Conclusion: The results of our study showed that serum levels of IL-8 and IL-6 were significantly higher in patients compared to controls.

引用

页码：522 / 525

页数：4

共 24 条

[1]

ALDALAAN A, 1995, J RHEUMATOL, V22, P904

[2] IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS) [J].

Bazrafshani, MR ;

Hajeer, AH ;

Ollier, WER ;

Thornhill, MH .

GENES AND IMMUNITY, 2002, 3 (05) :302-305

[3] Elevated levels of interferon gamma, tumor necrosis factor α, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis [J].

Buño, IJ ;

Huff, C ;

Weston, WL ;

Cook, DT ;

Brice, SL .

ARCHIVES OF DERMATOLOGY, 1998, 134 (07) :827-831

[4]

HAYRINENIMMONEN R, 1992, SCAND J DENT RES, V100, P222

[5]

HAYRINENIMMONEN R, 1991, SCAND J DENT RES, V99, P510

[6]

Hoffmann E, 2002, J LEUKOCYTE BIOL, V72, P847

[7] Adamantiades-Behcet's disease: Serum IL-8 is a more reliable marker for disease activity than C-reactive protein and erythrocyte sedimentation rate [J].

Katsantonis, J ;

Adler, Y ;

Orfanos, CE ;

Zouboulis, CC .

DERMATOLOGY, 2000, 201 (01) :37-39

[8]

LANDESBERG R, 1999, J MAXILLO FACIAL SUR, V25, P480

[9] Recurrent aphthous stomatitis revisited; clinical features, associations, and new association with infant feeding practices? [J].

McCullough, Michael John ;

Abdel-Hafeth, Samah ;

Scully, Crispian .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2007, 36 (10) :615-620

[10] Immunolocalization of tumor necrosis factor-α expressing cells in recurrent aphthous ulcer lesions (RAU) [J].

Natah, SS ;

Häyrinen-Immonen, R ;

Hietanen, J ;

Malmström, M ;

Konttinen, YT .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2000, 29 (01) :19-25

← 1 2 3 →