Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals:: formation of S ∴N three-electron bonded radical complexes

被引：22
|
作者：
Nauser, T [1 ]
Jacoby, M
Koppenol, WH
Squier, TC
Schöneich, C
机构：
[1] Swiss Fed Inst Technol, Inorgan Chem Lab, CH-8093 Zurich, Switzerland
[2] Pacific NW Natl Lab, Richland, WA USA
[3] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66045 USA
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 05期
关键词：
D O I：
10.1039/b414687e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The one-electron oxidation of calmodulin, studied on the microsecond timescale by pulse radiolysis, leads to methionine sulfide radical cations, which complex to adjacent amide groups to form three-electron bonded intermediates.
引用
收藏
页码：587 / 589
页数：3
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