Synthesis of novel 1,3-dioxolane nucleoside analogues

被引：0

作者：

Cai, DM

Lin, KH

Li, MZ

Wen, JW

Li, HY

You, TP ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Anhua 230026, Peoples R China

[2] Shanghai Univ, Dept Chem, Shanghai 200436, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2004年 / 22卷 / 12期

关键词：

nucleoside; 1,3-dioxolane; tiazofurin; ribavirin; imidazole;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel 1,3-dioxolane C-nucleoside analogues of tiazofurin 2-(2-hydroxymethyl-1,3-dioxolan-4-yl)-1,3-thiazole-4-carboxamide as well as N-nucleoside analogues of substituted imidazoles 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4-nitroimidazole and 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4,5-dicyanoimidazole were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, H-1 NMR, C-13 NMR spectra and elemental analysis.

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页码：1425 / 1431

页数：7

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