Epigenetic modifications of histones during osteoblast differentiation

被引：16
作者：
Adithya, S. Pranav [1 ]
Balagangadharan, K. [1 ]
Selvamurugan, N. [1 ]
机构：
[1] SRM Inst Sci & Technol, Coll Engn & Technol, Dept Biotechnol, Kattankulathur 603203, Tamil Nadu, India
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2022年 / 1865卷 / 01期
关键词：
Epigenetics; Histone modifiers; Osteoblast differentiation; Bone; MESENCHYMAL STEM-CELLS; MATRIX METALLOPROTEINASE-13 TRANSCRIPTION; MARROW STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; GENE-EXPRESSION; BONE-FORMATION; POSTTRANSLATIONAL MODIFICATIONS; DNA METHYLATION; RUNX2; GENE; ACETYLATION;
D O I：
10.1016/j.bbagrm.2021.194780
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In bone biology, epigenetics plays a key role in mesenchymal stem cells' (MSCs) commitment towards osteo-blasts. It involves gene regulatory mechanisms governed by chromatin modulators. Predominant epigenetic mechanisms for efficient osteogenic differentiation include DNA methylation, histone modifications, and non-coding RNAs. Among these mechanisms, histone modifications critically contribute to altering chromatin configuration. Histone based epigenetic mechanisms are an essential mediator of gene expression during oste-oblast differentiation as it directs the bivalency of the genome. Investigating the importance of histone modi-fications in osteogenesis may lead to the development of epigenetic-based remedies for genetic disorders of bone. Hence, in this review, we have highlighted the importance of epigenetic modifications such as post-translational modifications of histones, including methylation, acetylation, phosphorylation, ubiquitination, and their role in the activation or suppression of gene expression during osteoblast differentiation. Further, we have emphasized the future advancements in the field of epigenetics towards orthopaedical therapeutics.
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页数：14
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