Extracellular vesicles in kidneys and their clinical potential in renal diseases

被引：13

作者：

Lee, Sul A. ^{[1
,2
,3
]}

Choi, Chulhee ^{[4
,5
]}

Yoo, Tae-Hyun ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

[2] Yonsei Univ, Coll Med, Inst Kidney Dis Res, 50-1 Yonsei Ro, Seoul 03722, South Korea

[3] MetroWest Med Ctr, Dept Internal Med, Framingham, MA USA

[4] ILIAS Biol Inc, 40-20 Techno 6 Ro, Daejeon 34014, South Korea

[5] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon, South Korea

来源：

KIDNEY RESEARCH AND CLINICAL PRACTICE | 2021年 / 40卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Biomarkers; Exosomes; Extracellular vesicles; Immunity; Kidney diseases; Microvesicles; TUBULAR EPITHELIAL-CELLS; URINARY EXOSOMES; MESSENGER-RNA; DIABETIC-NEPHROPATHY; ENDOTHELIAL-CELLS; NONCODING RNAS; IN-VITRO; BIOMARKER; MICROVESICLES; ANGIOGENESIS;

D O I：

10.23876/j.krcp.20.209

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver information from host cells to recipient cells. EVs are involved in various biological processes including the modulation of the immune response, cell-to-cell communications, thrombosis, and tissue regeneration. Different types of kidney cells are known to release EVs under physiologic as well as pathologic conditions, and recent studies have found that EVs have a pathophysiologic role in different renal diseases. Given the recent advancement in EV isolation and analysis techniques, many studies have shown the diagnostic and therapeutic potential of EVs in various renal diseases, such as acute kidney injury, polycystic kidney disease, chronic kidney disease, kidney transplantation, and renal cell carcinoma. This review updates recent clinical and experimental findings on the role of EVs in renal diseases and highlights the potential clinical applicability of EVs as novel diagnostics and therapeutics.

引用

页码：194 / 207

页数：14

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