Innate immune sensing and its roots: the story of endotoxin

被引：1044
作者：
Beutler, B [1 ]
Rietschel, ET
机构：
[1] Scripps Res Inst, La Jolla, CA 92037 USA
[2] Res Ctr Borstel, D-23845 Borstel, Germany
来源：
NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors - the Toll-like receptors - was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.
引用
收藏
页码：169 / 176
页数：8
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