Small-molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides

被引：145

作者：

Hergenrother, PJ ^{[1
]}

Depew, KM ^{[1
]}

Schreiber, SL ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Hravard Inst Chem & Cell BIol, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 32期

关键词：

D O I：

10.1021/ja0014032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：7849 / 7850

页数：2

共 12 条

[1]

Chalet L., 1964, ARCH BIOCHEM BIOPHYS, V106, P1

[2] Combinational chemistry gives cell biology some muscle [J].

Hall, DG .

NATURE BIOTECHNOLOGY, 2000, 18 (03) :261-262

[3] A RECEPTOR FOR THE IMMUNOSUPPRESSANT FK506 IS A CIS-TRANS PEPTIDYL-PROLYL ISOMERASE [J].

HARDING, MW ;

GALAT, A ;

UEHLING, DE ;

SCHREIBER, SL .

NATURE, 1989, 341 (6244) :758-760

[4]

Hattori K., UNPUB

[5] DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12 [J].

HOLT, DA ;

LUENGO, JI ;

YAMASHITA, DS ;

OH, HJ ;

KONIALIAN, AL ;

YEN, HK ;

ROZAMUS, LW ;

BRANDT, M ;

BOSSARD, MJ ;

LEVY, MA ;

EGGLESTON, DS ;

LIANG, J ;

SCHULTZ, LW ;

STOUT, TJ ;

CLARDY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (22) :9925-9938

[6] Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis [J].

Lee, DS ;

Sello, JK ;

Schreiber, SL .

ORGANIC LETTERS, 2000, 2 (05) :709-712

[7] Printing small molecules as microarrays and detecting protein-ligand interactions en masse [J].

MacBeath, G ;

Koehler, AN ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (34) :7967-7968

[8] Target-oriented and diversity-oriented organic synthesis in drug discovery [J].

Schreiber, SL .

SCIENCE, 2000, 287 (5460) :1964-1969

[9] A CYTOSOLIC BINDING-PROTEIN FOR THE IMMUNOSUPPRESSANT FK506 HAS PEPTIDYL-PROLYL ISOMERASE ACTIVITY BUT IS DISTINCT FROM CYCLOPHILIN [J].

SIEKIERKA, JJ ;

HUNG, SHY ;

POE, M ;

LIN, CS ;

SIGAL, NH .

NATURE, 1989, 341 (6244) :755-757

[10] Synthesis and characterization of DNA-modified silicon (111) surfaces [J].

Strother, T ;

Cai, W ;

Zhao, XS ;

Hamers, RJ ;

Smith, LM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (06) :1205-1209

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